Senior Investigator

Jianjun LIU, Ph.D.
Senior Group Leader, Human Genetics
Deputy Director, Research Programmes
 
Research Focus

Research interest of my lab is to understand the biological basis of disease inheritance. Mainly focusing on complex diseases, my lab is pursuing collaborative research to discover genetic variants that influence disease susceptibility, progression and treatment outcome by employing both hypothesis-driven and genome-wide association analyses. Largely working on Asian populations, my lab is currently researching on diverse disease phenotypes, including cancers, autoimmune and inflammatory diseases, neurological and psychiatric disorders, cardiovascular and infectious diseases. Supported by strong funding from the Biomedical Research Council and National Medical Research Council of Singapore, the collaborative research by my lab has led to the discovery of many novel disease susceptibility genes for human diseases.

Moving beyond the discovery of novel disease susceptibility loci, my lab is also working towards to understanding biological mechanisms underlining novel disease susceptibility loci through genetic fine mapping analysis and functional investigation in in vitro cellular and in vivo animal model systems. My lab is also interested in exploring the integration of genetic and genomic analyses in order to gain more mechanistic insights into the biological basis of human disease inheritance. Furthermore, because the extent and distribution of disease predisposing genetic variation in the human species today is the result of a long and complicated evolutionary, migratory, and demographic history, my lab is also interested in investigating population processes affecting genetic variations in modern human populations. Such population genetics research can not only improve our understanding of the population structure of modern Human species, but also further facilitate our studies of complex disease.



Education

1991-1997Ph.D., Quantitative Genetics, Duke University, Durham, NC, USA.
1986-1989M.S., Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, Chandong, PR China
1981-1986B.S., Biology, University of Science & Technology of China, Hefei, Anhui, China


Professional Appointments

2012-PresentDeputy Director, Research Programmes, Genome Institute of Singapore, A*STAR, Singapore
2010-PresentSenior Group Leader, Human Genetics, Genome Institute of Singapore, A*STAR, Singapore
2013-PresentAdjunct Professor, Saw Swee Hock School of Public Health, National University of Singapore, Singapore
2013-PresentAdjunct Senior Principal Research Scientist, Singapore Eye Research Institute, Singapore
2009-2011Associate Director, Human Genetics, Genome Institute of Singapore, A*STAR, Singapore
2007-2010Group Leader, Human Genetics, Genome Institute of Singapore, A*STAR, Singapore
2003-2004Adjunct Research Fellow, Centre for Molecular Epidemiology, National University of Singapore, Singapore
2002-2006Senior Research Scientist, Population Genetics, Genome Institute of Singapore, A*STAR, Singapore
2000-20022000-2002 Research Scientist, Columbia Genome Center, Columbia University, New York, NY, USA
1998-2000Research Scientist in Molecular Genetics, New York State Psychiatric Institute, New York, NY, USA
1997-2000Postdoctoral Research Fellow, Columbia Genome Center and Department of Psychiatry, College Physicians and Surgeons at Columbia University, New York, NY, USA
1989-1991Research Assistant, Institute of Oceanology, Chinese Academy of Science, Qingdao, China


Honors and Awards


1991Fellowship, Duke University
1999-2000Young Investigator Award, National Alliance For Research On Schizophrenia and Depression
2000-2001Young Investigator Award, Cure Autism Now Foundation
2010 Chen Young Investigator Award, Human Genome Organization (HUGO)


Committee and Advisory Board

2003Member, Domain-Specific Review Board C, National Health Group, Singapore
2002Member, Peripheral, Central, Sensory & Cellular Nervous System/Mental Health Subcommittee, National Medical Research Council, Singapore
2008Member, Pharmacogenetics Advisory Committee, Healthy Sciences Authority, Singapore
2010Member, the Singapore Local Review Panel for the 2nd A*STAR-New Zealand HRC Joint Grant Call
2009-presentMember, HUGO Publication Committee, Human Genome Organization
2009-PresentAssociate Editor, BMC Genetics
2012-PresentMember, the Singapore Local Review Panel for the New Investigator Grant, National Medical Research Council, Singapore
2014-Associate Editor, Journal of Human Genetics


Selected Publications

  1. Zhang FR, Liu H, Irwanto A, Fu XA, Li Y, Yu GQ, Yu YX, Chen MF, Low HQ, Li JH, Bao FF, Foo JN, Bei JX, Jia XM, Liu J, Liany H, Wang N, Niu GY, Wang ZZ, Shi BQ, Tian HQ, Liu HX, Ma SS, Zhou Y, You JB, Yang Q, Wang C, Chu TS, Liu DC, Yu XL, Sun YH, Ning Y, Wei ZH, Chen SL, Chen XC, Zhang ZX, Liu YX, Pulit SL, Wu WB, Zheng ZY, Yang RD, Long H, Liu ZS, Wang JQ, Li M, Zhang LH, Wang H, Wang LM, Xiao P, Li JL, Huang ZM, Huang JX, Li Z, Liu J, Xiong L, Yang J, Wang XD, Yu DB, Lu XM, Zhou GZ, Yan LB, Shen JP, Zhang GC, Zeng YX, de Bakker PI, Chen SM, Liu JJ "HLA-B*13:01 and the dapsone hypersensitivity syndrome." N Engl J Med 2013 Oct 24 ; 369(17) : 1620-8 Abstract     

  2. Tan DE, Foo JN, Bei JX, Chang J, Peng R, Zheng X, Wei L, Huang Y, Lim WY, Li J, Cui Q, Chew SH, Ebstein RP, Kuperan P, Lim ST, Tao M, Tan SH, Wong A, Wong GC, Tan SY, Ng SB, Zeng YX, Khor CC, Lin D, Seow AL, Jia WH, Liu J. Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nat Genet. 2013 Jun 9;45(7):804-7.

  3. Foo JN, Liu JJ, Tan EK "Whole-genome and whole-exome sequencing in neurological diseases." Nat Rev Neurol. 2012 Sep;8(9):508-17. Abstract     

  4. Lin Z, Bei JX, Shen M, Li Q, Liao Z, Zhang Y, Lv Q, Wei Q, Low HQ, Guo YM, Cao S, Yang M, Hu Z, Xu M, Wang X, Wei Y, Li L, Li C, Li T, Huang J, Pan Y, Jin O, Wu Y, Wu J, Guo Z, He P, Hu S, Wu H, Song H, Zhan F, Liu S, Gao G, Liu Z, Li Y, Xiao C, Li J, Ye Z, He W, Liu D, Shen L, Huang A, Wu H, Tao Y, Pan X, Yu B, Tai ES, Zeng YX, Ren EC, Shen Y, Liu J, Gu J "A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis." Nat Genet 2011 Dec 4 Epub 2011 Dec 4 Abstract     

  5. Yu XQ, Li M, Zhang H, Low HQ, Wei X, Wang JQ, Sun LD, Sim KS, Li Y, Foo JN, Wang W, Li ZJ, Yin XY, Tang XQ, Fan L, Chen J, Li RS, Wan JX, Liu ZS, Lou TQ, Zhu L, Huang XJ, Zhang XJ, Liu ZH, Liu JJ. "A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy." Nat Genet. 2011 Dec 25;44(2):178-82. doi: 10.1038/ng.1047.

  6. Bei JX, Li Y, Jia WH, Feng BJ, Zhou G, Chen LZ, Feng QS, Low HQ, Zhang H, He F, Tai ES, Kang T, Liu ET, Liu J, Zeng YX. "A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci." Nat Genet. 2010 Jul;42(7):599-603. Epub 2010 May 30. Abstract     

  7. Sheng D, Qu D, Kwok KH, Ng SS, Lim AY, Aw SS, Lee CW, Sung WK, Tan EK, Lufkin T, Jesuthasan S, Sinnakaruppan M, Liu J "Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect." PLoS Genet 2010 ; 6(4) : e1000914 Epub 2010 Apr 22 Abstract     

  8. Zhang FR, Huang W, Chen SM, Sun LD, Liu H, Li Y, Cui Y, Yan XX, Yang HT, Yang RD, Chu TS, Zhang C, Zhang L, Han JW, Yu GQ, Quan C, Yu YX, Zhang Z, Shi BQ, Zhang LH, Cheng H, Wang CY, Lin Y, Zheng HF, Fu XA, Zuo XB, Wang Q, Long H, Sun YP, Cheng YL, Tian HQ, Zhou FS, Liu HX, Lu WS, He SM, Du WL, Shen M, Jin QY, Wang Y, Low HQ, Erwin T, Yang NH, Li JY, Zhao X, Jiao YL, Mao LG, Yin G, Jiang ZX, Wang XD, Yu JP, Hu ZH, Gong CH, Liu YQ, Liu RY, Wang DM, Wei D, Liu JX, Cao WK, Cao HZ, Li YP, Yan WG, Wei SY, Wang KJ, Hibberd ML, Yang S, Zhang XJ, Liu JJ. "Genomewide association study of leprosy." N Engl J Med. 2009 Dec 31;361(27):2609-18. Epub 2009 Dec 16. Abstract     

  9. Chen J, Zheng H, Bei JX, Sun L, Jia WH, Li T, Zhang F, Seielstad M, Zeng YX, Zhang X, Liu J. "Genetic structure of the Han Chinese population revealed by genome-wide SNP variation." Am J Hum Genet. 2009 Dec;85(6):775-85. Epub 2009 Nov 26. Abstract     

  10. Zhang XJ, Huang W, Yang S, Sun LD, Zhang FY, Zhu QX, Zhang FR, Zhang C, Du WH, Pu XM, Li H, Xiao FL, Wang ZX, Cui Y, Hao F, Zheng J, Yang XQ, Cheng H, He CD, Liu XM, Xu LM, Zheng HF, Zhang SM, Zhang JZ, Wang HY, Cheng YL, Ji BH, Fang QY, Li YZ, Zhou FS, Han JW, Quan C, Chen B, Liu JL, Lin D, Fan L, Zhang AP, Liu SX, Yang CJ, Wang PG, Zhou WM, Lin GS, Wu WD, Fan X, Gao M, Yang BQ, Lu WS, Zhang Z, Zhu KJ, Shen SK, Li M, Zhang XY, Cao TT, Ren W, Zhang X, He J, Tang XF, Lu S, Yang JQ, Zhang L, Wang DN, Yuan F, Yin XY, Huang HJ, Wang HF, Lin XY, Liu JJ. "Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21." Nat. Genet. 2009 Feb;41(2):205-10. Abstract     



Complete Publications List



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