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RESEARCH FOCUS
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Research Interests:
My earlier work focused on the discovery of kinases involved in cancer biology and in molecular clinical epidemiology. During this period, I discovered and investigated a new class of receptor tyrosine kinases (AXL) involved in invasion and metastases, and determined the importance of HER2 in modulating breast cancer response to specific forms of adjuvant chemotherapy. Since 1998, my scientific research has focused on the functional genomics of human cancers investigating the dynamics of gene regulation on a genome scale that modulates cancer biology. We have explored the expression signatures in breast cancers that define biochemical and genetic perturbations. From this point, we have pursued the transcriptional regulation by estrogen receptor on a genomic scale. Collectively, my work spans cancer biology, genomics, human genetics, and molecular epidemiology.
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EDUCATION
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| 1983-1987 | Postdoctoral Fellow - Dept. of Microbiology, University of California at San Francisco, CA (Dr. J. Michael Bishop) | | 1982-1985 | Hematology Fellowship, University of California San Francisco, Moffitt Hospital | | 1980-1982 | Oncology Fellowship, Stanford University | | 1979-1980 | Residency, Barnes Hospital - Washington University, St. Louis | | 1978-1979 | Internship, Barnes Hospital - Washington University, St. Louis | | 1973-1978 | Stanford University, M.D. | | 1969-1973 | Stanford University, B.S. Chemistry, Psychology |
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PROFESSIONAL APPOINTMENTS
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| Present | Executive Director, Genome Institute of Singapore |
| Present | Professor of Medicine, National University of Singapore, Special Advisor to the Vice Chancellor |
| Present | Executive Director, Singapore Cancer Syndicate |
| Present | Executive Director, Singapore Tissue Network |
| 2007 | Visiting Scientist, RIKEN Institute, Japan |
| Nov 2006-present | Adjunct Professor of Johns Hopkins, Division of Molecular Medicine, Department of Medicine |
| Present | Adjunct Professor of Molecular and Cellular Biology at the University of Champaign-Urbana. |
| Present | Professor, Department of Community, Occupational and Family Medicine (COFM), National University of Singapore |
| 1996-2001 | Director, Division of Clinical Sciences, National Cancer Institute, Bthesda, MD |
| 1995-1996 | Chief, Division of Medical Genetics, School of Medicine |
| 1995-1996 | Professor, Departments of Medicine, Epidemiology, Biochemistry and Biophysics. |
| 1993-1995 | Associate Professor, Departments of Medicine and Epidemiology and Biochemistry, University of North Carolina at Chapel Hill |
| 1992-1996 | Director, Specialized Program of Research Excellence in Breast Cancer(NIH Designated) |
| 1987-1993 | Assistant Professor in Medicine and Oncology, School of Medicine University of North Carolina at Chapel Hill |
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HONORS AND AWARDS
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| 2008 | Associate (Foriegn) Member European Molecular Biology Organization (EMBO) |
| 2007 | Doctor of Medical Science honoris causa - Awarded by Queen's University Belfast |
| 2005 | National Healthcare Group (NHG), Singapore, Distinguished Contributor Award |
| 2003 | Public Service Medal (National Day, 2003): for work in controlling SARS in Singapore (given by the Office of the President, Republic of Singapore) |
| 2000 | Rosenthal Award, AACR: for the discovery that HER-2 status determines response to adjuvant chemotherapy with doxorubicin. |
| 1999 | Elected-Board of Directors, American Association for Cancer Research |
| 1996 | 1996 Brinker International Award for Breast Cancer Research - Basic Research Award |
| 1995 | American Society of Clinical Investigation (Membership) |
| 1991-1996 | Leukemia Society Scholar |
| 1990-1994 | Jefferson Pilot Award: University of North Carolina at Chapel Hill, Junior Faculty Award for Research Excellence |
| 1990-1993 | Komen Foundation Award for Breast Cancer Research (funding fellow salary) |
| 1985-1988 | Clinical Investigator Award, National Cancer Institute, K08-CA01036-02, Preceptor: Dr. J. Michael Bishop. |
| 1983-1985 | Damon Runyan Cancer Fund Fellowship Preceptor: Dr. J. Michael Bishop (UCSF) |
| 1974 | Ford Foundation Fellowship for Intensive Studies in Chinese, Stanford University |
| 1973 | Phi Beta Kappa Stanford University |
| 1972 | National Science Foundation Fellowship in Chemistry 1972. |
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COMMITTEE AND ADVISORY BOARD
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| 2007-2009 | President, HUGO (Human Genome Organisation) |
| 2007-2009 | Chairman, Health Sciences Authority (HSA), Singapore |
| 2007-present | Keystone Symposia Scientific Advisory Board |
| 2006 | Board Member, National Healthcare Group (NHG), Singapore |
| 2006 | Deputy Chairman, Health Sciences Authority (HSA), Singapore |
| 2005-2008 | Member, NUS High School Board of Governors |
| 2006 | Member, Editorial Advisory Board, Biomolecular Frontiers, National University of Singapore (NUS) |
| 2005 | Member, Search Committee for Deputy President (Research & Technology, NUS) |
| 2004 | FANTOM3 working group member. |
| 2004 | University Autonomy, Governance, and Funding Steering Committee (MOE, Singapore, Member) |
| 2003 | Bioethics Advisory Committee (Member), Singapore |
| 2002-2003 | National Health Group, Strategic Committee for Clinical Research (Singapore) |
| 2002 | Biomedical Sciences Executive Committee, A*STAR (Singapore) |
| 2002-2006 | General Motors Award, General Assembly (USA) |
| 2002 | National University of Singapore: Feasibility study team for the establishment of a multicampus university. |
| 2002 | Ministerial committee to revaluate Singapore’s secondary school system (Ministry of Education) |
| 2001 | President’s Life Sciences Committee (National University of Singapore) |
| 2001 | University Promotion and Tenuring Committee (National University of Singapore) |
| 2001-2003 | Genetically Modified Organisms Advisory Council (Singapore Government) |
| 2000-2001 | NCI-Ireland-Northern Ireland Cancer Consortium Governing Board (Member) |
| 1999-2000 | Chair, General Motors Cancer Research Awards Committee: Mott Award |
| 1999-2001 | NIH Committee to establish NIH graduate program |
| 1998-2001 | NIH Building 10 Revitalization Committee |
| 1997-1998 | NCI Breast Cancer Program Review Group |
| 1997-2001 | NIH Clinical Research Revitalization Committee |
| 1997-2001 | Co-Chair, NIH Clinical Center Advisory Council |
| 1997 | Chairman, NIH Committee on Extramural/Intramural Investigations in the Clinical Center |
| 1997 | Molecular Epidemiology Coordinating Group, NCI |
| 1997 | SBRS Policy Board, NIH |
| 1996 | AACR - Clinical Cancer Research Committee, 1996 |
| 1996 | NCI - Clinical Trials Working Group, 1996 |
| 1996 | NCI - Cancer Genetics Working Group, 1996 |
| 1996 | NCI - Developmental Diagnostics Working Group, 1996 |
| 1996-1997 | NIH Committee on the Recruitment and Career Development of Clinical Investigators |
| 1996 | Protocol Review and Monitoring Committee, NCI |
| 1996 | Faculty Search Committee, Division of Molecular Genetics |
| 1996 | Executive Committee: Clinical Cancer Program |
| 1996 | Advisory Committee: Clinical Cancer Program |
| 1995-1996 | National Action Plan on Breast Cancer - Biological Resources Working Group |
| 1994 | Faculty Search Committee: Cell Biology Program, Lineberger Cancer Center |
| 1992-1994 | American Society for Clinical Oncology: Program Committee |
| 1990-1992 | Lineberger Cancer Center, SPA personnel compensation Committee |
| 1992 | Faculty Search Committee Program in Molecular Biology |
| 1990 | Lineberger Cancer Center Planning Committee 14th Annual Symposium |
| 1989 | Lineberger Cancer Center Seminar Committee |
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EXTERNAL GRANT
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15/05/2007-14/05/2010 |
Pair-end-ditag technologies for the complete annotation of fusion genes by
National Cancer Institute (USA) (USD$1,300,000)
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09/01/2004 – 06/30/2007 |
Ditag technologies for complete transcriptome annotation by
National Institutes of Health (USD1,050,000)
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06/01/2004 – 05/31/2006 |
Genetic and environmental determinants of postmenopausal breast cancer by
Susan G Komen Foundation ($952,057)
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SELECTED PUBLICATIONS
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1. Jiang X, Tan J, Li J, Kivimäe S, Yang X, Zhuang L, Lee PL, Chan MT, Stanton LW, Liu ET, Cheyette BN, Yu Q. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell. Jun;13(6):529-41
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2. Bourque G, Leong B, Vega VB, Chen X, Lee YL, Srinivasan KG, Chew JL, Ruan Y, Wei CL, Ng HH, Liu ET. Evolution of the mammalian transcription factor binding repertoire via transposable elements. Genome Res. Aug 5
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3. Liu ET. Functional genomics of cancer. Curr Opin Genet Dev. 2008 Aug 5.
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4. Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, Karuturi RK, Tan PB, Liu ET, Yu Q. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. Apr 16
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5. Chin-Yo Lin, Vinsensius B. Vega, Jane S. Thomsen, Tao Zhang, Say Li Kong, Min Xie, Kuo Ping Chiu, Leonard Lipovich, Daniel H. Barnett, Fabio Stossi, Ailing Yeo, Joshy George, Vladimir A. Kuznetsov, Yew Kok Lee, Tze Howe Charn, Nallasivam Palanisamy, Lance D. Miller, Edwin Cheung, Benita S. Katzenellenbogen, Yijun Ruan, Guillaume Bourque, Chia-Lin Wei, Edison T. Liu. Whole-genome Cartography of Estrogen Receptor α Binding Sites. PLoS Genetics Jun 1;3(6):e87
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6. Vega VB, Lin CY, Lai KS, Kong SL, Xie M, Su X, Teh HF, Thomsen JS, Yeo AL, Sung WK, Bourque G, Liu ET. Multi-platform genome-wide identification and modeling of functional human estrogen receptor binding sites. Genome Biol. Sep 9;7(9):R82
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7. Zhao Y, Tan J, Zhuang L, Jiang Xia, Edison Tak-Bun LIU, Qiang YU (In Press) "Inhibitors of histon deacetylases target Rb-E2F1 pathway for apoptosis induction through transcriptional activation of proapoptotic protein Bim" PNAS, November 1, 2005, Vol 102, No. 44, 16090-16095
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8. Lance D MILLER, Edison Tak-Bun LIU, Klaar S, Hall P, Pawitan Y, Ploner A, Vergara L, Vega VB, George J, Smeds J, Bergh J (2005) "An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects and patient survival" Proc Natl Acad Sci U S A 102(38) 13550-5
Abstract
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9. Qiu TH, Chandramouli GV, Hunter KW, Alkharouf NW, Green JE, Edison Tak-Bun LIU (2004) "Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT transgenic mice: correlation to human disease" Cancer Res 64(17) 5973-81
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10. Yijun RUAN, Chia Lin WEI, Ling Ai Ee, Vinsensius Berlian VEGA, Thoreau Herve, Su Yun Se Thoe, Chia Jer-Ming, Patrick Wei Pern NG, Kuo Ping CHIU, Lim Landri, Zhang Tao, Chan Kwai Peng, Lynette Oon Lin Ean, Ng Mah Lee, Leo Yee Sin, Lisa Fong-Poh NG, Ee Chee REN, Lawrence STANTON, Long M. Philip, Edison Tak-Bun LIU (2003) "Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection" Lancet 361 (9371) 1779-85
Abstract
Supplemental Data File
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COMPLETE PUBLICATION LIST
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