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GHI |
JKL |
MNO |
PQRS |
TUV |
WXYZ
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RESEARCH FOCUS
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My current research interests cover both pathogen and host aspects of infectious disease, understanding how microbial agents causes the observed disease (including pathogen identification and sequence characterization) and why specific individuals are susceptible to the disease (using host genetics on a genomic scale). Approaching infectious disease from these two directions also allows specific host pathogen responses to be investigated (utilizing RNA microarrays), both in patients and model systems. This work aims to identify key host responses to specific pathogens that could be targeted by new therapies. Current disease areas include, Dengue, TB, Kawasaki Disease, Meningococcal disease, respiratory syncytial virus and Inflammatory Bowel Disease
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EDUCATION
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| 1994 | King's College, London University: Ph.D. (Medicine) | | 1985 | Brunel University (West London):B.Sc.(Hons)Applied Biology |
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PROFESSIONAL APPOINTMENTS
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| 2003-date | A. Prof, Dept Microbiology, Faculty of Medicine, National University of Singapore. |
| 1996-date | Senior Lecturer (Infectious Disease), Dept. Paediatrics, Imperial College Faculty of Medicine, St Mary's Hospital, Padington, London, UK. |
| 1993-1996 | Post doctoral fellow, Dept. Medicine, Plymouth Post Graduate Medical School, UK |
| 1990-1993 | Research Associate , King's College School of Medicine and Dentistry, Denmark Hill, London, UK |
| 1988-1990 | Senior Microbiologist, Public Health Laboratory Service (PHLS), Head office, Colindale, London |
| 1986-1988 | Medical Laboratory Scientific Officer, PHLS Center for Applied Microbiology and Research, Porton Down, Salisbury, UK |
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COMMITTEE AND ADVISORY BOARD
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| 2006 to 2009 | A*STAR BMRC grant awarding committee |
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EXTERNAL GRANT
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2009 to 2012 |
A data-driven integrated epidemiological model of dengue spread in Singapore through data-mining, mathematical modelling, vector surveillance and educational outreach by
A*STAR cross council (S$581,000)
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2009 to 2012 |
Development of a high throughput molecular tool for strain identification and resistance profiling of Mycobacterium tuberculosis by
DARPA (USA) (US$300,000)
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2009 to 2011 |
A genome Wide association study for Dengue Shock Syndrome. by
Wellcome Trust, UK (US$1,000,000)
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2009 to 2010 |
The Effects of Interferon Alfa-2a (PEGASYS®) in Patients with Chronic Hepatitis B. by
Roche (S$200,000)
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2009 to 2010 |
Validation of biomarkers for dengue disease prognosis by
Novartis (S$150,000)
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2008 to 2013 |
Scientific exploration, translational research, operational evaluation of disease prevention and preventative measures through new treatment strategies against Dengue (STOP Dengue) by
Ministry of Health “Translational and Clinical Research (TCR) Flagship Program (S$25,000,000)
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2007 to 2012 |
Funding for SMART (Singapore MIT Alliance for Research and Technology) Interdisciplinary Research Group in Infectious Disease by
National Research Foundation (US$25,000,000)
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2007 to 2010 |
Identification of immunological correlates of dengue disease severity, using clinical samples taken serially from primary and secondary cases. by
Singapore Immunology Network (S$ 1,292,620)
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2006 to 2007 |
Identification of novel inflammation check points by
DARPA (USA) (US$300,000)
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2005 to 2008 |
Characterization of HiB vaccine Failure in the UK using large scale immunogenetics. by
European Society for Pediatric Infectious Disease (UK) (GBP 300,000)
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2005 to 2008 |
International Consortium for Identification of the genetic basis of susceptibility and severity of meningococcal septicemia and meningitis. by
European Society for Pediatric Infectious Disease (UK) (GBP 150,000)
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2005 to 2006 |
Collection of clinical samples for Dengue research. by
Bio Medical Research Council, Singapore. (S$190,000)
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PATENTS
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2010 |
Provisional patent No. 201002998-1 :
4. Methods and/or primers for the detection of influenza A (Filed)
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2008 |
Provi/US. Filing Date 15-May-08 :
Kawasaki Disease diagnosis and treatment (Filed)
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2006 |
PCT/SG2007/000336 :
Dengue Diagnosis and treatment. (Filed)
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2003 |
60/454,115 :
Detection of severe acute respiratory syndrome (Filed)
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CURRENT PERSONNEL
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Ms Hazel Wong (Graduate Student)
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Eileen Png (Research Officer)
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Ms Lim Chui Chin (Research Officer)
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Anna Elizabeth Lindblom (Post Doctoral Fellow)
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Khor Chiea Chean (Post Doctoral Fellow)
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Dr Sonia Davila (Research Scientist)
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Ms Ling Ling (Research Officer)
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Dr Ranjeeta Hari Dass (Post Doctoral Fellow)
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Ms Aw Poh Kim Pauline (Research Officer)
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Ahmad Nazri Mohd Naim (Research Officer)
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Christophe Lay (Post Doctoral Fellow)
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Ms Bok Chek Mei (Research Officer)
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PREVIOUS PERSONNEL
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Dr Wang Shugui (GIS Position: PDF)
Current Position: Duke-NUS
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Dr Tang kin Fai (GIS Position: PDF)
Current Position: Duke-NUS
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SELECTED PUBLICATIONS
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1. McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D\'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M "Genome-wide association identifies multiple ulcerative colitis susceptibility loci." Nat Genet 2010 Mar 14 Epub 2010 Mar 14
Abstract
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2. Lee VJ, Yap J, Cook AR, Chen MI, Tay JK, Tan BH, Loh JP, Chew SW, Koh WH, Lin R, Cui L, Lee CW, Sung WK, Wong CW, Hibberd ML, Kang WL, Seet B, Tambyah PA "Oseltamivir Ring Prophylaxis for Containment of 2009 H1N1 Influenza Outbreaks." N Engl J Med 2010 Jun 10 ; 362(23) : 2166-2174
Abstract
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3. Zhang FR, Huang W, Chen SM, Sun LD, Liu H, Li Y, Cui Y, Yan XX, Yang HT, Yang RD, Chu TS, Zhang C, Zhang L, Han JW, Yu GQ, Quan C, Yu YX, Zhang Z, Shi BQ, Zhang LH, Cheng H, Wa ng CY, Lin Y, Zheng HF, Fu XA, Zuo XB, Wang Q, Long H, Sun YP, Cheng YL, Tian HQ, Zhou FS, Liu HX, Lu WS, He SM, Du WL, Shen M, Jin QY, Wang Y, Low HQ, Erwin T, Yang NH, Li JY, Zhao X, Jiao YL, Mao LG, Yin G, Jiang ZX, Wang XD, Yu JP, Hu ZH, Gong CH, Liu YQ, Liu RY, Wang DM, Wei D, Liu JX, Cao WK, Cao HZ, Li YP, Yan WG, Wei SY, Wang KJ, Hibberd ML, Yang S, Zhang XJ, Liu JJ "Genomewide association study of leprosy." N Engl J Med 2009 Dec 31 ; 361(27) : 2609-18 Epub 2009 Dec 16
Abstract
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4. Schreiber Mark J, Holmes Edward C, Ong Swee Hoe, Soh Harold S H, Liu Wei, Tanner Lukas, Aw Pauline P K, Tan Hwee Cheng, Ng Lee Ching, Leo Yee Sin, Low Jenny G H, Ong Adrian, Ooi Eng Eong, Vasudevan Subhash G, Hibberd Martin L "Genomic Epidemiology of a Dengue Virus Epidemic in Urban Singapore." J. Virol. 2009 Feb 11 ; :
Abstract
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5. Burgner David, Davila Sonia, Breunis Willemijn B, Ng Sarah B, Li Yi, Bonnard Carine, Ling Ling, Wright Victoria J, Thalamuthu Anbupalam, Odam Miranda, Shimizu Chisato, Burns Jane C, Levin Michael, Kuijpers Taco W, Hibberd Martin L, International Kawasaki Disease Genetics Consortium "A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease." PLoS Genet. 2009 Jan ; 5(1) : e1000319
Abstract
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6. Long Hoang Truong, Hibberd Martin L, Hien Tran Tinh, Dung Nguyen Minh, Ngoc Tran Van, Farrar Jeremy, Wills Bridget, Simmons Cameron P "Patterns of Gene Transcript Abundance in the Blood of Children with Severe or Uncomplicated Dengue Highlight Differences in Disease Evolution and Host Response to Dengue Virus Infection." J. Infect. Dis. 2009 Jan 12 ; :
Abstract
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7. Davila Sonia, Hibberd Martin L, Hari Dass Ranjeeta, Wong Hazel E E, Sahiratmadja Edhyana, Bonnard Carine, Alisjahbana Bachti, Szeszko Jeffrey S, Balabanova Yanina, Drobniewski Francis, van Crevel Reinout, van de Vosse Esther, Nejentsev Sergey, Ottenhoff Tom H M, Seielstad Mark "Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis." PLoS Genet. 2008 Oct ; 4(10) : e1000218
Abstract
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8. Nejentsev S, Thye T, Szeszko JS, Stevens H, Balabanova Y, Chinbuah AM, Hibberd M, van de Vosse E, Alisjahbana B, van Crevel R, Ottenhoff TH, Png E, Drobniewski F, Todd JA, Seielstad M, Horstmann RD. Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations.Nat Genet. 2008 Mar;40(3):261-2;
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9. Wong Christopher W, Heng Charlie Lee Wah, Wan Yee Leong, Soh Shirlena W L, Kartasasmita Cissy B, Simoes Eric A F, Hibberd Martin L, Sung Wing-Kin, Miller Lance D "Optimization and clinical validation of a pathogen detection microarray." Genome Biol. 2007 ; 8(5) : R93
Abstract
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10. Liu Jianjun, Lim Siew Lan, Ruan Yijun, Ling Ai Ee, Ng Lisa F P, Drosten Christian, Liu Edison T, Stanton Lawrence W, Hibberd Martin L "SARS transmission pattern in Singapore reassessed by viral sequence variation analysis." PLoS Med. 2005 Feb ; 2(2) : e43
Abstract
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COMPLETE PUBLICATION LIST
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