| |
| |
|
| |
ALL |
ABC |
DEF |
GHI |
JKL |
MNO |
PQRS |
TUV |
WXYZ
|
|
|
|
GIS MENTORING SCIENTIST
|
With the advance of genotyping technology and HAPMAP project, the population association study to detect genomic variants that affect the susceptibility of common human disease has welcomed a new member of GWAS (genome-wide association study), with its traditional approach of candidate gene strategy still popular. However, given the medium sample size, few of the top-ranked SNPs in the initail GWAS stage, based on P-values, were validated in independent samples. One of my recent research interest is to develop methods of re-ranking SNPs in GWAS that promote the true risk allele to higher rankings based on new ranking scores. My other research interest include joint association and interaction analysis among a large number of SNPs within a pathway, haplotype analysis-based fine mapping.
I am also interested in CNV association analysis, meta-analysis, mircoarray gene expression data analysis, variable/model selection.
|
|
|
EDUCATION
|
| 1997-2000 | PhD, Computer Science, National Univ. of Singapore, Singapore | | 1990-1993 | M.E., Computer Science, Xian Jiaotong Univ., Xian, China | | 1986-1990 | B.S., Computer Science, Xian Jiaotong Univ., Xian, China |
|
|
PROFESSIONAL APPOINTMENTS
|
| 2007-present | research scientist at Human Genetics, Genome Institute of Singapore |
| 2002-2006 | Postdoc at Computational and Mathematical Biology, Genome Institute of Singapore |
| 2001-2002 | Postdoc at Dept. of Engineering Mathematics, Univ. of Bristol. U.K. |
|
|
HONORS AND AWARDS
|
| 1996 | fellowship,Marconi Inc. U.K. |
| 1997-2000 | scholarship,NUS, Singapore |
| 2001 | IDA gold medal for the best PhD thesis, NUS |
|
|
SELECTED PUBLICATIONS
|
1. Kristjana Einarsdóttir, Hatef Darabi, Yi Li, Yen Ling Low, Yu Qing Li, Carine Bonnard, Arvid Sjolander, Kamila Czene, Sara Wedrén, Edison T Liu, Per Hall, Keith Humphreys and Jianjun Liu. ESR1 and EGF genetic variation in relation to breast cancer risk and survival, Breast Cancer Research, 10 (1), 2008.
|
2. Li, Y. and Sung, W.K. and Liu, J.J. Association mapping via regularized regression analysis of single-nucleotide–polymorphism haplotypes in variable-sized sliding windows, The American Journal of Human Genetics, 80:705-715, 2007
|
3. Kristjana Einarsdóttir, Lena U. Rosenberg, Keith Humphreys, Carine Bonnard, Juni Palmgren, Yuqing Li, Yi Li, Kee Seng Chia, Edison T. Liu, Per Hall, Jianjun Liu and Sara Wedrén. Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study, Breast Cancer research, 8:R67, 2006.
|
4. Kristjana Einarsdóttir, Keith Humphreys, Carine Bonnard, Yuqing Li, Yi Li, Kee Seng Chia, Edison T. Liu, Per Hall, Jianjun Liu and Sara Wedrén. Effect of ATM, CHEK2 and ERBB2 tagSNPs and Haplotypes on Endometrial Cancer Risk, Human Molecular Genetics, 16(2):154-164, 2006.
|
5. Liu*, T.F. and Sung*, W-K and Li*, Y. and et. al. Effective algorithms for Tag SNP selection, Journal of Bioinformatics and Computational Biology, 3:1089-1106, 2005 (*: equally contributed)
|
6. Lisa, S. and Li, Y. and Bonnard, C. and Pavanni, R. and Yih, Y. and Chua, E. and Sung, W.K. and Tan, L. and Wong, M.C. and Tan, E.K. and Liu, J.J. Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson’s disease, Human Molecular Genetics, 14:3549-3556, 2005.
|
7. Li, Y. and Long, P. The Relaxed Online Maximum Margin Algorithm, Machine Learning, special issue on support vector machines and kernel methods, Vol. 46, No. 3, pp361-388, 2002
|
8. Li, Y. and Campbell, C. and Tipping, M. Bayesian automatic relevance determination algorithms for classifying gene expression data, Bioinformatics, vol 18, No 10, pp1332-1339, 2002
|
9. Li, Y. and Long, P. and Srinivasan, A. The One-Inclusion Graph Algorithm is Near-Optimal for the Prediction Model of Learning. IEEE Transactions on Information Theory, Vol. 47, No. 3, pp1257–1261, 2001
|
10. Li, Y. and Long, P. and Srinivasan, A. Improved Bounds on the Sample Complexity of Learning. Journal of Computer and System Sciences, Vol. 62, No. 3, pp516-527, 2001
|
|
|
COMPLETE PUBLICATION LIST
|
 Please Click Here
|
|
| |
|
| |
|
|
|
