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GIS MENTORING SCIENTIST
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More and more empirical evidence has shown that high-order interactions of SNPs and haplotypes within genes play an important role in explaining the differences between low and high risk groups. One of our current research interests is to develop parametric models of these interactions in case-control association studies. On another direction, we explore new model selection strategies to improve the performance of standard methods in differentiating potentially causative from non-causative variants.
My other research interests including: Linkage and QTL Mapping; SNP discovery; longitudinal data analysis and functional data analysis; bayesian modeling of functional mapping; and developing statistical methods for expression quantitative trait loci (eQTL) mapping.
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EDUCATION
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| 2007 | Ph.D., Statistics University of Florida, USA | | 2004 | M.S., Statistics University of Florida, USA | | 2001 | B.S., Applied Mathematics Fudan University, China |
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PROFESSIONAL APPOINTMENTS
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| 2007-present | Research Scientist, Genome Institute of Singapore, Singapore |
| 2004-2007 | Research Assistant, Department of Statistics, University of Florida |
| 2003-2004 | Teaching Assistant, Department of Statistics, University of Florida |
| 2001-2002 | Mathematics Teacher, Kingsford Community School, London UK |
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HONORS AND AWARDS
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| 2002-2007 | Alumni Graduate Fellowship, University of Florida |
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SELECTED PUBLICATIONS
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1. Liu, T., A. Thalamuthu., J. J. Liu, C. Chen., and R. L. Wu, (2010) A Model for Testing Epistatic Interactions of Complex Diseases in Case-Control Studies. Biostatistics. (Accepted, second submission).
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2. Hou Wei, Liu Tian, Li Yao, Li Qin, Li Jiahan, Das Kiranmoy, Berg Arthur, Wu Rongling "Multilocus genomics of outcrossing plant populations." Theor Popul Biol 2009 Aug ; 76(1) : 68-76 Epub 2009 May 6
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3. Liu T., Wu R. A Bayesian Algorithm for Functional Mapping of Dynamic Complex Traits. Algorithms. 2009; 2(2):667-691.
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4. Wang, C. G., Y. Cheng, T. Liu, Q. Li, R. Fillingim, P. Wallace, R. Staud, L. Kaplan and R. L. Wu, (2008) A computational model for sex-specific genetic architecture of complex traits in humans. Molecular Pain 4:13.
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5. Liu, T., R. J. Todhunter, S. Wu, W. Hou, R. Mateescu, Z. W. Zhang, N. I. Burton-Wurster, G. M. Acland, G. Lust and R. L. Wu, (2007) A random model for mapping imprinted quantitative trait loci in a structured pedigree: An implication for mapping canine hip dysplasia. Genomics 90: 276-284 (selected as a feature article).
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6. Wu, R. L., W. Hou, Y. H. Cui, H. Y. Li, T. Liu, S. Wu, C.-X. Ma and Y. R. Zeng, (2007). Mapping the genetic architecture of complex traits with molecular markers. Recent Patents on Nanotechnology 1: 41-49 (invited review article).
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7. Liu, T., R. J. Todhunter, G. Casella, R. Mateescu, Z. W. Zhang, N. I. Burton-Wurster, G. M. Acland, G. Lust, and R. L. Wu. (2007). Imprinted quantitative trait loci for canine hip dysplasia. Genomics 90: 276-284
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8. Liu, T., R. J. Todhunter, Q. Lu, H. Y. Li, R. C. Littell, S. Bliss, G. Acland, G. Lust, and R. L. Wu. (2006). Extent and distribution of zygotic linkage disequilibrium in canine. Genetics, 174, 439-453
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9. Liu, T., W. Zhao, L. L. Tian, and R. L. Wu. (2005). An algorithm for molecular dissection of tumor progression. Journal of Mathematical Biology, 50, 336-354
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10. Liu, T., J. A. Johnson, G. Casella, and R. L. Wu. (2004). Sequencing complex diseases with HapMap. Genetics, 168, 503-511
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COMPLETE PUBLICATION LIST
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