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RESEARCH FOCUS
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My lab is interested in understanding the molecular details of nuclear hormone signaling and how these pathways relate to disease conditions, including cancers. Currently, we are investigating how estrogens and antiestrogens (therapeutic agents used in breast cancer treatment) regulate the transcriptional activities of estrogen receptors in the context of a chromatin environment. My lab employs a combination of powerful biological tools, including modern genetic and cell-based techniques (RNAi and ChIP) and a unique in vitro chromatin assembly and transcription system, to define the molecular mechanisms of transcriptional regulation by estrogen receptors. The findings from our work will have direct applications towards the development of therapeutic targets for the wide range of diseases and disorders in which estrogen and other nuclear receptors play a role.
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EDUCATION
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| 1999-2004 | Postdoctoral Fellow-Dept. of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
| | 1995-1999 | PhD-School of Biological Sciences, University of Manchester, UK
| | 1988-1992 | BA Biochemistry and Molecular Biology-Dept. of Molecular Biology and Cell Biology, University of California, Berkeley, CA, USA
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PROFESSIONAL APPOINTMENTS
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| 2006- | Adjunct Assistant Professor-Department of Biochemistry, National University of Singapore |
| 2006- | Adjunct Assistant Professor-School of Biological Sciences, Nanyang Technological University |
| 2004- | Senior Research Scientist-Genome Institute of Singapore
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| 1992-1995 | Research Assistant-Dept. of Molecular Biology and Cell Biology, University of California, Berkeley, CA, USA
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HONORS AND AWARDS
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| 2003-2004 | NIH NRSA Postdoctoral Fellowship |
| 2001 | The Endocrine Society Travel Grant
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| 2000-2003 | Susan G. Komen Breast Cancer Foundation Postdoctoral Fellowship
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| 1996-1998 | Overseas Research Studentship Award
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| 1995-1998 | Frederick Craven Moore Research Studentship Award
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SELECTED PUBLICATIONS
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1. *Cheung, E., and *Kraus, W.L. (2010) "Genomic Analyses of Hormone Signaling and Gene Regulation" Annual Review of Physiology 72, 191-218. (*Co-corresponding authors)
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2. Vega, V.B., Cheung, E., Palanisamy, N., and Sung, W.K. (2009) "Inherent Signals in Sequencing-Based Chromatin-ImmunoPrecipitation Control Libraries" PloS ONE 4 (4), e5241.
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3. Fullwood, M.J., Liu, M.H., Pan, Y.F., Liu, J., Xu, H., Mohamed, Y.B., Orlov, Y.L., Velkov, S., Ho, A., Huang, P.Y.H., Chew, E.G.Y., Yao, P., Huang, H., Welboren, W-J., Han, Y., Ooi, H.S., Ariyaratne, P.N., Vega, V.B., Luo, Y., Tan, P.Y., Choy, P.Y., Abayratna, K.D.S., Zhao, B., Lim, K.S., Leow, S.C., Yow, J.S., Joseph, R., Li, H., Desai, K.V., Thomsen, J.S., Lee, Y.K., Karuturi, R.K.M., Herve, T., Bourque, G., Stunnenberg, H.G., Ruan, X., Cacheux-Rataboul, V., Sung, K.W.K., Liu, E.T., Wei, C.L., *Cheung, E., and *Ruan, Y. (2009) "An Oestrogen Receptor α-Bound Human Chromatin Interactome" Nature 482 (7269), 58-64. (*Co-corresponding authors)
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4. Pan, Y.F., Abayratna, S., Liu, M.H., Zhao, B., Hong, S.Z., Tan, P.Y., Lim, K.S., Bourque, G., Liu, E.T., and Cheung, E. (2008) "Regulation of estrogen receptor-mediated long–range transcription via evolutionarily conserved distal response elements" The Journal of Biological Chemistry 283 (47), 32977-88.
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5. Zhao, Y., Hamza, M.S., Leong, H.S., Lim, C.B., Pan, Y.F., Cheung, E., Soo, K.C., and Iyer, N.G. (2008) "Kruppel-Like Factor 5 Modulates p53-Independent Apoptosis Through Pim1 Survival Kinase in Cancer Cells" Oncogene 27 (1), 1-8.
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6. Lin, C.Y., Vega, V.B., Thomsen, J.S., Zhang, T., Kong, S.L., Xie, M., Chiu, K.P., Lipovich, L., Barnett, D.H., Stossi, F., Yeo, A., George, J., Kuznetsov, V.A., Lee, Y.K., Charn, T.H., Palanisamy, N., Miller, L.D., Cheung, E., Katzenellenbogen, B.S., Ruan, Y., Bourque, G., Wei, C.L., and Liu, E.T. (2007) "Whole-genome cartography of estrogen receptor α binding sites" PLoS Genetics 3(6), e87.
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7. *Ross, S., *Cheung, E., Howell, M., Petrakis, T.G., Kraus, W.L., and Hill, C.S. (2006) "Smads orchestrate specific histone modifications
and chromatin remodeling to activate transcription" The EMBO Journal 25 (19), 4490-502. (*Equal contributions)
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8. Cheung, E., Acevedo, M.L., Cole, P.A., and Kraus, W.L. (2005) "Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1" Proceedings of the National Academy of Sciences 102 (3), 559-64.
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9. Cheung, E., Schwabish, M.A., and Kraus, W.L. (2003) "Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors alpha and beta" The EMBO Journal 22 (3), 600-11.
Abstract
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10. Cheung, E., Zarifyan, A.S., and Kraus, W.L. (2002) "Histone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation" Molecular Cellular Biology 22 (8), 2463-71.
Abstract
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