Publications from 2014
  1. "2013 runme shaw memorial lecture: clinical applications of stem cells in modern medicine-21st century and beyond." Ng HH (2014) Ann Acad Med Singapore 2014 Jan ; 43(1) : 68-71


  2. "2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy." Li J, Lindström LS, Foo JN, Rafiq S, Schmidt MK, Pharoah PD, Michailidou K, Dennis J, Bolla MK, Wang Q, Van \'t Veer LJ, Cornelissen S, Rutgers E, Southey MC, Apicella C, Dite GS, Hopper JL, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Blomqvist C, Muranen TA, Aittomäki K, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Hartikainen JM, Kataja V, Chenevix-Trench G, Investigators k, Phillips KA, McLachlan SA, Lambrechts D, Thienpont B, Smeets A, Wildiers H, Chang-Claude J, Flesch-Janys D, Seibold P, Rudolph A, Giles GG, Baglietto L, Severi G, Haiman CA, Henderson BE, Schumacher F, Le Marchand L, Kristensen V, Alnæs GI, Borresen-Dale AL, Nord S, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Devilee P, Tollenaar R, Seynaeve C, Hooning M, Kriege M, Hollestelle A, van den Ouweland A, Li Y, Hamann U, Torres D, Ulmer HU, Rüdiger T, Shen CY, Hsiung CN, Wu PE, Chen ST, Teo SH, Taib NA, Har Yip C, Fuang Ho G, Matsuo K, Ito H, Iwata H, Tajima K, Kang D, Choi JY, Park SK, Yoo KY, Maishman T, Tapper WJ, Dunning A, Shah M, Luben R, Brown J, Khor CC, Eccles DM, Nevanlinna H, Easton D, Humphreys K, Liu J, Hall P, Czene K (2014) Nat Commun 2014 ; 5 : 4051


  3. "A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort." Nag A, Venturini C, Small KS, Young TL, Viswanathan AC, Mackey DA, Hysi PG, Hammond CJ (2014) Hum Mol Genet 2014 Feb 11


  4. "ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma." Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair KS, Cheng CY, Xu L, George R, Tan D, Abu-Amero K, Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin LS, Ho CL, Tham CC, Soto I, Chew PT, Wong HT, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VH, Ting SM, Li Y, Wang YX, Li Z, Lavanya R, Wu RY, Zheng YF, Su DH, Loon SC, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia KS, Kumaramanickavel G, Wong TT, How AC, Chau TN, Simmons CP, Bei JX, Zeng YX, Bhattacharya SS, Zhang M, Tan DT, Teo YY, Al-Obeidan SA, Hon do N, Tai ES, Saw SM, Foster PJ, Vijaya L, Jonas JB, Wong TY, John SW, Pang CP, Vithana EN, Wang N, Aung T (2014) PLoS Genet 2014 Mar ; 10(3) : e1004089 Epub 2014 Mar 6


  5. "Analysis of nonsynonymous coding variants of Parkinson's disease-related pathogenic and susceptibility genes in East Asian populations." Foo JN, Tan LC, Liany H, Koh TH, Irwan ID, Ng YY, Ahmad-Annuar A, Au WL, Aung T, Chan AY, Chong SA, Chung SJ, Jung Y, Khor CC, Kim J, Lee J, Lim SY, Mok V, Prakash KM, Song K, Tai ES, Vithana EN, Wong TY, Tan EK, Liu J (2014) Hum Mol Genet 2014 Feb 23


  6. "CMPK1 and RBP3 are associated with corneal curvature in Asian populations." Chen P, Miyake M, Fan Q, Liao J, Yamashiro K, Ikram MK, Chew M, Vithana EN, Khor CC, Aung T, Tai ES, Wong TY, Teo YY, Yoshimura N, Saw SM, Cheng CY (2014) Hum Mol Genet 2014 Jun 24


  7. "Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure." Fang F, Xu Y, Chew KK, Chen X, Ng HH, Matsudaira P (2014) Stem Cells 2014 Mar 19


  8. "Detection of chromosomal breakpoints in patients with developmental delay and speech disorders." Utami KH, Hillmer AM, Aksoy I, Chew EG, Teo AS, Zhang Z, Lee CW, Chen PJ, Seng CC, Ariyaratne PN, Rouam SL, Soo LS, Yousoof S, Prokudin I, Peters G, Collins F, Wilson M, Kakakios A, Haddad G, Menuet A, Perche O, Tay SK, Sung KW, Ruan X, Ruan Y, Liu ET, Briault S, Jamieson RV, Davila S, Cacheux V (2014) PLoS One 2014 ; 9(3) : e90852 Epub 2014 Mar 6


  9. "Different hereditary contribution of the CFH gene between Polypoidal Choroidal Vasculopathy and Age-Related Macular Degeneration in Chinese Han people." Huang L, Li Y, Guo S, Sun Y, Zhang C, Bai Y, Li S, Yang F, Zhao M, Wang B, Yu W, Zhao M, Khor CC, Li X (2014) Invest Ophthalmol Vis Sci 2014 Apr 1


  10. "EZH2-Mediated Inactivation of IFN-γ-JAK-STAT1 Signaling Is an Effective Therapeutic Target in MYC-Driven Prostate Cancer." Wee ZN, Li Z, Lee PL, Lee ST, Lim YP, Yu Q (2014) Cell Rep 2014 Jun 17


  11. "Gene-Age Interactions in Blood Pressure Regulation: A Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia." Simino J, Shi G, Bis JC, Chasman DI, Ehret GB, Gu X, Guo X, Hwang SJ, Sijbrands E, Smith AV, Verwoert GC, Bragg-Gresham JL, Cadby G, Chen P, Cheng CY, Corre T, de Boer RA, Goel A, Johnson T, Khor CC, Lluís-Ganella C, Luan J, Lyytikäinen LP, Nolte IM, Sim X, Sõber S, van der Most PJ, Verweij N, Zhao JH, Amin N, Boerwinkle E, Bouchard C, Dehghan A, Eiriksdottir G, Elosua R, Franco OH, Gieger C, Harris TB, Hercberg S, Hofman A, James AL, Johnson AD, Kähönen M, Khaw KT, Kutalik Z, Larson MG, Launer LJ, Li G, Liu J, Liu K, Morrison AC, Navis G, Ong RT, Papanicolau GJ, Penninx BW, Psaty BM, Raffel LJ, Raitakari OT, Rice K, Rivadeneira F, Rose LM, Sanna S, Scott RA, Siscovick DS, Stolk RP, Uitterlinden AG, Vaidya D, van der Klauw MM, Vasan RS, Vithana EN, Völker U, Völzke H, Watkins H, Young TL, Aung T, Bochud M, Farrall M, Hartman CA, Laan M, Lakatta EG, Lehtimäki T, Loos RJ, Lucas G, Meneton P, Palmer LJ, Rettig R, Snieder H, Tai ES, Teo YY, van der Harst P, Wareham NJ, Wijmenga C, Wong TY, Fornage M, Gudnason V, Levy D, Palmas W, Ridker PM, Rotter JI, van Duijn CM, Witteman JC, Chakravarti A, Rao DC (2014) Am J Hum Genet 2014 Jun 18


  12. "Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development." Moule MG, Hemsley CM, Seet Q, Guerra-Assunção JA, Lim J, Sarkar-Tyson M, Clark TG, Tan PB, Titball RW, Cuccui J, Wren BW (2014) MBio 2014 ; 5(1) : e00926-13


  13. "Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility." (2014) Nat Genet 2014 Feb 9


  14. "Genomic characterization of three unique Dehalococcoides that respire on persistent polychlorinated biphenyls." Wang S, Chng KR, Wilm A, Zhao S, Yang KL, Nagarajan N, He J (2014) Proc Natl Acad Sci U S A 2014 Jul 15


  15. "Genotype-Phenotype Correlation Analysis for Three Primary Angle Closure Glaucoma Associated Genetic Polymorphisms." Wei X, Nongpiur ME, De Leon JM, Baskaran M, Perera SA, How AC, Vithana EN, Khor CC, Aung T (2014) Invest Ophthalmol Vis Sci 2014 Jan 28


  16. "iCall: A genotype-calling algorithm for rare, low-frequency and common variants on the Illumina exome array." Zhou J, Tantoso E, Wong LP, Ong RT, Bei JX, Li Y, Liu J, Khor CC, Teo YY (2014) Bioinformatics 2014 Feb 23


  17. "Identifiability and privacy in pluripotent stem cell research." Isasi R, Andrews PW, Baltz JM, Bredenoord AL, Burton P, Chiu IM, Hull SC, Jung JW, Kurtz A, Lomax G, Ludwig T, McDonald M, Morris C, Ng HH, Rooke H, Sharma A, Stacey GN, Williams C, Zeng F, Knoppers BM (2014) Cell Stem Cell 2014 Apr 3 ; 14(4) : 427-30


  18. "Impact of measurement error on testing genetic association with quantitative traits." Liao J, Li X, Wong TY, Wang JJ, Khor CC, Tai ES, Aung T, Teo YY, Cheng CY (2014) PLoS One 2014 ; 9(1) : e87044 Epub 2014 Jan 24


  19. "Insights into the genetic structure and diversity of 38 South asian indians from deep whole-genome sequencing." Wong LP, Lai JK, Saw WY, Ong RT, Cheng AY, Pillai NE, Liu X, Xu W, Chen P, Foo JN, Tan LW, Koo SH, Soong R, Wenk MR, Lim WY, Khor CC, Little P, Chia KS, Teo YY (2014) PLoS Genet 2014 May ; 10(5) : e1004377 Epub 2014 May 15


  20. "Intertumour heterogeneity of non-small cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics." Tan DS, Camilleri-Broët S, Tan EH, Alifano M, Lim WT, Bobbio A, Zhang S, Ng QS, Ang MK, Iyer NG, Takano A, Lim KH, Régnard JF, Tan P, Broët P (2014) Int J Cancer 2014 Jan 31


  21. "Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells." Aksoy I, Giudice V, Delahaye E, Wianny F, Aubry M, Mure M, Chen J, Jauch R, Bogu GK, Nolden T, Himmelbauer H, Xavier Doss M, Sachinidis A, Schulz H, Hummel O, Martinelli P, Hübner N, Stanton LW, Real FX, Bourillot PY, Savatier P (2014) Nat Commun 2014 ; 5 : 3719


  22. "Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue." Chan KR, Ong EZ, Tan HC, Zhang SL, Zhang Q, Tang KF, Kaliaperumal N, Lim AP, Hibberd ML, Chan SH, Connolly JE, Krishnan MN, Lok SM, Hanson BJ, Lin CN, Ooi EE (2014) Proc Natl Acad Sci U S A 2014 Feb 18 ; 111(7) : 2722-7 Epub 2014 Jan 13


  23. "Meta-Analysis of Genome-Wide Association Studies in Multiethnic Asians Identifies Two Loci for Age-Related Nuclear Cataract." Liao J, Su X, Chen P, Wang X, Xu L, Li X, Thean L, Tan C, Tan AG, Tay WT, Jun G, Zheng Y, Chew M, Wang YX, Tan QS, Barathi VA, Klein BE, Saw SM, Vithana EN, Tai ES, Iyengar SK, Mitchell P, Khor CC, Aung T, Wang JJ, Jonas JB, Teo YY, Wong TY, Cheng CY (2014) Hum Mol Genet 2014 Jun 20


  24. "MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling." Bhinge A, Poschmann J, Namboori SC, Tian X, Jia Hui Loh S, Traczyk A, Prabhakar S, Stanton LW (2014) EMBO J 2014 May 6


  25. "Multiple Non-glycemic Genomic Loci Are Newly Associated with Blood Level of Glycated Hemoglobin in East Asians." Chen P, Takeuchi F, Lee JY, Li H, Wu JY, Liang J, Long J, Tabara Y, Goodarzi MO, Pereira MA, Kim YJ, Go MJ, Stram DO, Vithana E, Khor CC, Liu J, Liao J, Ye X, Wang Y, Lu L, Young TL, Lee J, Thai AC, Cheng CY, van Dam RM, Friedlander Y, Heng CK, Koh WP, Chen CH, Chang LC, Pan WH, Qi Q, Isono M, Zheng W, Cai Q, Gao Y, Yamamoto K, Ohnaka K, Takayanagi R, Kita Y, Ueshima H, Hsiung CA, Cui J, Huey-Herng Sheu W, Rotter JI, Chen YD, Hsu C, Okada Y, Kubo M, Takahashi A, Tanaka T, van Rooij FJ, Ganesh SK, Huang J, Huang T, Gross MD, Assimes TL, Miki T, Shu XO, Qi L, Chen YT, Lin X, Aung T, Wong TY, Teo YY, Kim BJ, Kato N, Tai ES (2014) Diabetes 2014 Mar 19


  26. "Next-generation whole genome sequencing of dengue virus." Aw PP, de Sessions PF, Wilm A, Hoang LT, Nagarajan N, Sessions OM, Hibberd ML (2014) Methods Mol Biol 2014 ; 1138 : 175-95


  27. "Polypoidal choroidal vasculopathy and systemic lupus erythematosus." Chin Y, Bhargava M, Khor C, Cheung C, Wong T (2014) Lupus 2014 Jan 9


  28. "Stratification and delineation of gastric cancer signaling by in vitro transcription factor activity profiling and integrative genomics." Periasamy J, Muthuswami M, Rao DB, Tan P, Ganesan K (2014) Cell Signal 2014 May ; 26(5) : 880-94 Epub 2014 Jan 22


  29. "TACO: a general-purpose tool for predicting cell-type-specific transcription factor dimers." Jankowski A, Prabhakar S, Tiuryn J (2014) BMC Genomics 2014 ; 15(1) : 208 Epub 2014 Mar 19


  30. "The Opisthorchis viverrini genome provides insights into life in the bile duct." Young ND, Nagarajan N, Lin SJ, Korhonen PK, Jex AR, Hall RS, Safavi-Hemami H, Kaewkong W, Bertrand D, Gao S, Seet Q, Wongkham S, Teh BT, Wongkham C, Intapan PM, Maleewong W, Yang X, Hu M, Wang Z, Hofmann A, Sternberg PW, Tan P, Wang J, Gasser RB (2014) Nat Commun 2014 ; 5 : 4378


  31. "The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity." Lu X, Sachs F, Ramsay L, Jacques PÉ, Göke J, Bourque G, Ng HH (2014) Nat Struct Mol Biol 2014 Apr ; 21(4) : 423-5 Epub 2014 Mar 30


  32. "The role of SON in splicing, development, and disease." Lu X, Ng HH, Bubulya PA (2014) Wiley Interdiscip Rev RNA 2014 Apr 30


  33. "Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells." Mong J, Panman L, Alekseenko Z, Kee N, Stanton LW, Ericson J, Perlmann T (2014) Stem Cells 2014 Mar ; 32(3) : 609-22


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