Publications from 2012
  1. "A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer." Ng KP, Hillmer AM, Chuah CT, Juan WC, Ko TK, Teo AS, Ariyaratne PN, Takahashi N, Sawada K, Fei Y, Soh S, Lee WH, Huang JW, Allen JC, Woo XY, Nagarajan N, Kumar V, Thalamuthu A, Poh WT, Ang AL, Mya HT, How GF, Yang LY, Koh LP, Chowbay B, Chang CT, Nadarajan VS, Chng WJ, Than H, Lim LC, Goh YT, Zhang S, Poh D, Tan P, Seet JE, Ang MK, Chau NM, Ng QS, Tan DS, Soda M, Isobe K, Nöthen MM, Wong TY, Shahab A, Ruan X, Cacheux-Rataboul V, Sung WK, Tan EH, Yatabe Y, Mano H, Soo RA, Chin TM, Lim WT, Ruan Y, Ong ST (2012) Nat Med 2012 ; 18(4) : 521-8 Epub 2012 Mar 18


  2. "A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets." Deng N, Goh LK, Wang H, Das K, Tao J, Tan IB, Zhang S, Lee M, Wu J, Lim KH, Lei Z, Goh G, Lim QY, Tan AL, Sin Poh DY, Riahi S, Bell S, Shi MM, Linnartz R, Zhu F, Yeoh KG, Toh HC, Yong WP, Cheong HC, Rha SY, Boussioutas A, Grabsch H, Rozen S, Tan P (2012) Gut 2012 May ; 61(5) : 673-84 Epub 2012 Feb 7


  3. "A Divalent Ion Is Crucial in the Structure and Dominant-Negative Function of ID Proteins, a Class of Helix-Loop-Helix Transcription Regulators." Wong MV, Jiang S, Palasingam P, Kolatkar PR (2012) PLoS One 2012 ; 7(10) : e48591 Epub 2012 Oct 30


  4. "A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians." Png E, Alisjahbana B, Sahiratmadja E, Marzuki S, Nelwan R, Balabanova Y, Nikolayevskyy V, Drobniewski F, Nejentsev S, Adnan I, van de Vosse E, Hibberd ML, van Crevel R, Ottenhoff TH, Seielstad M (2012) BMC Med Genet 2012 Jan 13 ; 13(1) : 5 Epub 2012 Jan 13


  5. "A Genome-Wide Screen for Genetic Variants That Modify the Recruitment of REST to Its Target Genes." Johnson R, Richter N, Bogu GK, Bhinge A, Teng SW, Choo SH, Andrieux LO, de Benedictis C, Jauch R, Stanton LW (2012) PLoS Genet 2012 Apr ; 8(4) : e1002624 Epub 2012 Apr 5


  6. "A PRC2 Dependent Repressive role of PRDM14 in Human Embryonic Stem Cells and iPSC Reprogramming." Chan YS, Göke J, Lu X, Venkatesan N, Feng B, Su IH, Ng HH (2012) Stem Cells 2012 Dec 28


  7. "A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients." Nguyet NM, Chau TN, Lam PK, Kien DT, Huy HL, Farrar J, Quyen TH, Hien TT, Van Vinh Chau N, Merson L, Long HT, Hibberd ML, Aw PP, Wilm A, Nagarajan N, Dung NT, Mai PP, Truong NT, Javanbaht H, Klumpp K, Hammond J, Petric R, Wolbers M, Chinh NT, Simmons CP (2012) J Infect Dis 2012 Jul 17


  8. "A role for c-Abl in cell senescence and spontaneous immortalization." Zhang M, Li L, Wang Z, Liu H, Hou J, Zhang M, Hao A, Liu Y, He G, Shi Y, He L, Wang X, Wan Y, Li B (2012) Age (Dordr) 2012 Jul 13 Epub 2012 Jul 13


  9. "A role for polyamine regulators in ESC self-renewal." Zhao T, Goh KJ, Ng HH, Vardy LA (2012) Cell Cycle 2012 Dec 15 ; 11(24) : 4517-23 Epub 2012 Nov 19


  10. "Accurate identification of human Alu and non-Alu RNA editing sites." Ramaswami G, Lin W, Piskol R, Tan MH, Davis C, Li JB (2012) Nat Methods 2012 Jun ; 9(6) : 579-81 Epub 2012 Apr 4


  11. "Activin and BMP4 Synergistically Promote Formation of Definitive Endoderm in Human Embryonic Stem Cells." Teo AK, Ali Y, Wong KY, Chipperfield H, Sadasivam A, Poobalan Y, Tan EK, Wang ST, Abraham S, Tsuneyoshi N, Stanton LW, Dunn NR (2012) Stem Cells 2012 Apr ; 30(4) : 631-42


  12. "Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim. & Udagawa." Giridharan P, Verekar SA, Khanna A, Mishra PD, Deshmukh SK (2012) Indian J Exp Biol 2012 Jul ; 50(7) : 464-8


  13. "BatMis: A fast algorithm for k-mismatch mapping." Tennakoon C, Purbojati RW, Sung WK (2012) Bioinformatics 2012 Jun 10


  14. "Bridging the Gap: Understanding Embryonic Intervertebral Disc Development." Sivakamasundari Lufkin T (2012) Cell Dev Biol 2012 May ; 1(2) :


  15. "CD166(pos) Subpopulation From Differentiated Human ES and iPS Cells Support Repair of Acute Lung Injury." Soh BS, Zheng D, Li Yeo JS, Yang HH, Ng SY, Wong LH, Zhang W, Li P, Nichane M, Asmat A, Wong PS, Wong PC, Su LL, Mantalaris SA, Lu J, Xian W, McKeon F, Chen J, Lim EH, Lim B (2012) Mol Ther 2012 Sep 11 Epub 2012 Sep 11


  16. "CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis." Subramaniam D, Periyasamy G, Ponnurangam S, Chakrabarti D, Sugumar A, Padigaru M, Weir SJ, Balakrishnan A, Sharma S, Anant S (2012) Mol Cancer Ther 2012 Jul ; 11(7) : 1598-608 Epub 2012 Apr 24


  17. "Chromatin-Associated Proteins Revealed by SILAC-Proteomic Analysis Exhibit a High Likelihood of Requirement for Growth Fitness under DNA Damage Stress." Wang H, Tipthara P, Zhu L, Poon SY, Tang K, Liu J (2012) Int J Proteomics 2012 ; 2012 : 630409 Epub 2012 Aug 1


  18. "Circadian gene variants and susceptibility to type 2 diabetes: a pilot study." Kelly MA, Rees SD, Hydrie MZ, Shera AS, Bellary S, O\'Hare JP, Kumar S, Taheri S, Basit A, Barnett AH (2012) PLoS One 2012 ; 7(4) : e32670 Epub 2012 Apr 2


  19. "Cloning, purification and preliminary X-ray data analysis of the human ID2 homodimer." Wong MV, Palasingam P, Kolatkar PR (2012) un 2012 Nov 1 ; 68(Pt 11) : 1354-8 Epub 2012 Oct 30


  20. "Co-Motif Discovery Identifies an Esrrb-Sox2-Dna Ternary Complex as a Mediator of Transcriptional Differences Between Mouse Embryonic and Epiblast Stem Cells." Hutchins AP, Choo SH, Mistri TK, Rahmani M, Woon CT, Keow Leng Ng C, Jauch R, Robson P (2012) Stem Cells 2012 Nov 21


  21. "Comment on" Lin W, Piskol R, Tan MH, Li JB (2012) Science 2012 Mar 16 ; 335(6074) : 1302; author reply 1302


  22. "Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer." Wu Y, Grabsch H, Ivanova T, Tan IB, Murray J, Ooi CH, Wright AI, West NP, Hutchins GG, Wu J, Lee M, Lee J, Koo JH, Yeoh KG, van Grieken N, Ylstra B, Rha SY, Ajani JA, Cheong JH, Noh SH, Lim KH, Boussioutas A, Lee JS, Tan P (2012) t 2012 Jun 26


  23. "Computer and Statistical Analysis of Transcription Factor Binding and Chromatin Modifications by ChIP-seq data in Embryonic Stem Cell." Orlov Y, Xu H, Afonnikov D, Lim B, Heng JC, Yuan P, Chen M, Yan J, Clarke N, Orlova N, Huss M, Gunbin K, Podkolodnyy N, Ng HH (2012) J Integr Bioinform 2012 ; 9(2) : 211 Epub 2012 Sep 18


  24. "Constructing phylogenetic supernetworks based on simulated annealing." Hassanzadeh R, Eslahchi C, Sung WK (2012) Mol Phylogenet Evol 2012 Jun ; 63(3) : 738-44 Epub 2012 Mar 3


  25. "Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206." Liang Y, Choo SH, Rossbach M, Baburajendran N, Palasingam P, Kolatkar PR (2012) Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Apr 1 ; 68(Pt 4) : 443-7 Epub 2012 Mar 27


  26. "Deciphering the Sox-Oct partner code by quantitative cooperativity measurements." Ng CK, Li NX, Chee S, Prabhakar S, Kolatkar PR, Jauch R (2012) Nucleic Acids Res 2012 Feb 16


  27. "Deep Whole-Genome Sequencing of 100 Southeast Asian Malays." Wong LP, Ong RT, Poh WT, Liu X, Chen P, Li R, Lam KK, Pillai NE, Sim KS, Xu H, Sim NL, Teo SM, Foo JN, Tan LW, Lim Y, Koo SH, Gan LS, Cheng CY, Wee S, Yap EP, Ng PC, Lim WY, Soong R, Wenk MR, Aung T, Wong TY, Khor CC, Little P, Chia KS, Teo YY (2012) Am J Hum Genet 2012 Dec 31


  28. "Detection of long non-coding RNA in archival tissue: correlation with polycomb protein expression in primary and metastatic breast carcinoma." Chisholm KM, Wan Y, Li R, Montgomery KD, Chang HY, West RB (2012) PLoS One 2012 ; 7(10) : e47998 Epub 2012 Oct 25


  29. "Development and validation of Burkholderia pseudomallei-specific real-time PCR assays for clinical, environmental or forensic detection applications." Price EP, Dale JL, Cook JM, Sarovich DS, Seymour ML, Ginther JL, Kaufman EL, Beckstrom-Sternberg SM, Mayo M, Kaestli M, Glass MB, Gee JE, Wuthiekanun V, Warner JM, Baker A, Foster JT, Tan P, Tuanyok A, Limmathurotsakul D, Peacock SJ, Currie BJ, Wagner DM, Keim P, Pearson T (2012) PLoS One 2012 ; 7(5) : e37723 Epub 2012 May 18


  30. "Diabetes with hypertension as risk factors for adult dengue hemorrhagic Fever in a predominantly dengue serotype 2 epidemic: a case control study." Pang J, Salim A, Lee VJ, Hibberd ML, Chia KS, Leo YS, Lye DC (2012) PLoS Negl Trop Dis 2012 May ; 6(5) : e1641 Epub 2012 May 1


  31. "Directing Neuronal Differentiation of Primary Neural Progenitor Cells by Gene Knockdown Approach." Low WC, Yau WW, Stanton LW, Marcy G, Goh E, Chew SY (2012) DNA Cell Biol 2012 Feb 17


  32. "DNA-dependent Oct4-Sox2 interaction and diffusion properties characteristic of the pluripotent cell state revealed by fluorescence spectroscopy." Lam CS, Mistri TK, Foo YH, Sudhaharan T, Gan HT, Rodda D, Lim LH, Chou C, Robson P, Wohland T, Ahmed S (2012) Biochem J 2012 Nov 15 ; 448(1) : 21-33


  33. "Dynamic deposition of histone variant H3.3 accompanies developmental remodeling of the Arabidopsis transcriptome." Wollmann H, Holec S, Alden K, Clarke ND, Jacques PÉ, Berger F (2012) PLoS Genet 2012 May ; 8(5) : e1002658 Epub 2012 May 3


  34. "Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease." Soldati C, Bithell A, Johnston C, Wong KY, Stanton LW, Buckley NJ (2012) J Neurochem 2012 Nov 12


  35. "Efficient iodine catalyzed three components domino reaction for the synthesis of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives possessing anticancer activities." Ramachandran G, Karthikeyan NS, Giridharan P, Sathiyanarayanan KI (2012) Org Biomol Chem 2012 Jul 28 ; 10(28) : 5343-6 Epub 2012 Jun 14


  36. "Endogenous tagging of the murine transcription factor Sox5 with hemaglutinin for functional studies." Lee WJ, Kraus P, Lufkin T (2012) Transgenic Res 2012 Apr ; 21(2) : 293-301 Epub 2011 Jul 6


  37. "Exome sequencing and digital PCR analyses reveal novel mutated genes related to the metastasis of pancreatic ductal adenocarcinoma." Zhou B, Irwanto A, Guo YM, Bei JX, Wu Q, Chen G, Zhang TP, Lei JJ, Feng QS, Chen LZ, Liu J, Zhao YP (2012) Cancer Biol Ther 2012 Aug 1 ; 13(10) : 871-9 Epub 2012 Aug 1


  38. "Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes." Zang ZJ, Cutcutache I, Poon SL, Zhang SL, McPherson JR, Tao J, Rajasegaran V, Heng HL, Deng N, Gan A, Lim KH, Ong CK, Huang D, Chin SY, Tan IB, Ng CC, Yu W, Wu Y, Lee M, Wu J, Poh D, Wan WK, Rha SY, So J, Salto-Tellez M, Yeoh KG, Wong WK, Zhu YJ, Futreal PA, Pang B, Ruan Y, Hillmer AM, Bertrand D, Nagarajan N, Rozen S, Teh BT, Tan P (2012) Nat Genet 2012 Apr 8 Epub 2012 Apr 8


  39. "Exome sequencing of liver fluke-associated cholangiocarcinoma." Ong CK, Subimerb C, Pairojkul C, Wongkham S, Cutcutache I, Yu W, McPherson JR, Allen GE, Ng CC, Wong BH, Myint SS, Rajasegaran V, Heng HL, Gan A, Zang ZJ, Wu Y, Wu J, Lee MH, Huang D, Ong P, Chan-on W, Cao Y, Qian CN, Lim KH, Ooi A, Dykema K, Furge K, Kukongviriyapan V, Sripa B, Wongkham C, Yongvanit P, Futreal PA, Bhudhisawasdi V, Rozen S, Tan P, Teh BT (2012) Nat Genet 2012 Jun ; 44(6) : 690-3 Epub 2012 May 6


  40. "Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation." Li G, Ruan X, Auerbach RK, Sandhu KS, Zheng M, Wang P, Poh HM, Goh Y, Lim J, Zhang J, Sim HS, Peh SQ, Mulawadi FH, Ong CT, Orlov YL, Hong S, Zhang Z, Landt S, Raha D, Euskirchen G, Wei CL, Ge W, Wang H, Davis C, Fisher-Aylor KI, Mortazavi A, Gerstein M, Gingeras T, Wold B, Sun Y, Fullwood MJ, Cheung E, Liu E, Sung WK, Snyder M, Ruan Y (2012) Cell 2012 Jan 20 ; 148(1-2) : 84-98


  41. "First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway." Manu KA, Shanmugam MK, Ramachandran L, Li F, Fong CW, Kumar AP, Tan P, Sethi G (2012) Clin Cancer Res 2012 Apr 15 ; 18(8) : 2220-9 Epub 2012 Feb 20


  42. "First total synthesis of prasinic acid and its anticancer activity." Chakor N, Patil G, Writer D, Periyasamy G, Sharma R, Roychowdhury A, Mishra PD (2012) Bioorg Med Chem Lett 2012 Nov 1 ; 22(21) : 6608-10 Epub 2012 Sep 13


  43. "Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library." Zhou J, Chen GB, Tang YC, Sinha RA, Wu Y, Yap CS, Wang G, Hu J, Xia X, Tan P, Goh LK, Yen PM (2012) BMC Med Genomics 2012 ; 5 : 34 Epub 2012 Aug 9


  44. "Genetic variants on chromosome 1q41 influence ocular axial length and high myopia." Fan Q, Barathi VA, Cheng CY, Zhou X, Meguro A, Nakata I, Khor CC, Goh LK, Li YJ, Lim W, Ho CE, Hawthorne F, Zheng Y, Chua D, Inoko H, Yamashiro K, Ohno-Matsui K, Matsuo K, Matsuda F, Vithana E, Seielstad M, Mizuki N, Beuerman RW, Tai ES, Yoshimura N, Aung T, Young TL, Wong TY, Teo YY, Saw SM (2012) PLoS Genet 2012 Jun ; 8(6) : e1002753 Epub 2012 Jun 7


  45. "Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly." Lam ET, Hastie A, Lin C, Ehrlich D, Das SK, Austin MD, Deshpande P, Cao H, Nagarajan N, Xiao M, Kwok PY (2012) Nat Biotechnol 2012 Jul 15 Epub 2012 Jul 15


  46. "Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma." Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu L, Jia H, Ho CL, Sim KS, Wu RY, Tham CC, Chew PT, Su DH, Oen FT, Sarangapani S, Soumittra N, Osman EA, Wong HT, Tang G, Fan S, Meng H, Huong DT, Wang H, Feng B, Baskaran M, Shantha B, Ramprasad VL, Kumaramanickavel G, Iyengar SK, How AC, Lee KY, Sivakumaran TA, Yong VH, Ting SM, Li Y, Wang YX, Tay WT, Sim X, Lavanya R, Cornes BK, Zheng YF, Wong TT, Loon SC, Yong VK, Waseem N, Yaakub A, Chia KS, Allingham RR, Hauser MA, Lam DS, Hibberd ML, Bhattacharya SS, Zhang M, Teo YY, Tan DT, Jonas JB, Tai ES, Saw SM, Hon DN, Al-Obeidan SA, Liu J, Chau TN, Simmons CP, Bei JX, Zeng YX, Foster PJ, Vijaya L, Wong TY, Pang CP, Wang N, Aung T (2012) Nat Genet 2012 Aug 26 Epub 2012 Aug 26


  47. "Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis." Ottenhoff TH, Dass RH, Yang N, Zhang MM, Wong HE, Sahiratmadja E, Khor CC, Alisjahbana B, van Crevel R, Marzuki S, Seielstad M, van de Vosse E, Hibberd ML (2012) PLoS One 2012 ; 7(9) : e45839 Epub 2012 Sep 21


  48. "Genome-wide measurement of RNA folding energies." Wan Y, Qu K, Ouyang Z, Kertesz M, Li J, Tibshirani R, Makino DL, Nutter RC, Segal E, Chang HY (2012) Mol Cell 2012 Oct 26 ; 48(2) : 169-81 Epub 2012 Sep 13


  49. "Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells." Seo J, Kim SC, Lee HS, Kim JK, Shon HJ, Salleh NL, Desai KV, Lee JH, Kang ES, Kim JS, Choi JK (2012) Nucleic Acids Res 2012 Mar 29


  50. "Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma." Sung WK, Zheng H, Li S, Chen R, Liu X, Li Y, Lee NP, Lee WH, Ariyaratne PN, Tennakoon C, Mulawadi FH, Wong KF, Liu AM, Poon RT, Fan ST, Chan KL, Gong Z, Hu Y, Lin Z, Wang G, Zhang Q, Barber TD, Chou WC, Aggarwal A, Hao K, Zhou W, Zhang C, Hardwick J, Buser C, Xu J, Kan Z, Dai H, Mao M, Reinhard C, Wang J, Luk JM (2012) Nat Genet 2012 ; 44(7) : 765-9 Epub 2012 May 27


  51. "Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis." Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B (2012) Cell 2012 Jan 20 ; 148(1-2) : 259-72 Epub 2012 Jan 5


  52. "GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers." Li S, Qian J, Yang Y, Zhao W, Dai J, Bei JX, Foo JN, McLaren PJ, Li Z, Yang J, Shen F, Liu L, Yang J, Li S, Pan S, Wang Y, Li W, Zhai X, Zhou B, Shi L, Chen X, Chu M, Yan Y, Wang J, Cheng S, Shen J, Jia W, Liu J, Yang J, Wen Z, Li A, Zhang Y, Zhang G, Luo X, Qin H, Chen M, Wang H, Jin L, Lin D, Shen H, He L, de Bakker PI, Wang H, Zeng YX, Wu M, Hu Z, Shi Y, Liu J, Zhou W (2012) PLoS Genet 2012 Jul ; 8(7) : e1002791 Epub 2012 Jul 12


  53. "High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis." Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhe rnakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L, Toes RE, Huizinga TW, Wijmenga C, Trynka G, Franke L, Westra HJ, Alfredsson L, Hu X, Sandor C, de Bakker PI, Davila S, Khor CC, Heng KK, Andrews R, Edkins S, Hunt SE, Langford C, Symmons D, Concannon P, Onengut-Gumuscu S, Rich SS, Deloukas P, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Arlsetig L, Martin J, Rantapää-Dahlqvist S, Plenge RM, Raychaudhuri S, Klareskog L, Gregersen PK, Worthington J (2012) Nat Genet 2012 Nov 11 Epub 2012 Nov 11


  54. "Host-pathogen interactions revealed by human genome-wide surveys." Khor CC, Hibberd ML (2012) Trends Genet 2012 Mar 22


  55. "Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors." Ng SY, Johnson R, Stanton LW (2012) EMBO J 2012 Feb 1 ; 31(3) : 522-33 Epub 2011 Dec 23


  56. "Identification and Characterization of Mesenchymal Stem Cells Derived from the Trabecular Meshwork of the Human Eye." Tay CY, Sathiyanathan P, Chu SW, Stanton L, Wong TT (2012) Stem Cells Dev 2012 Feb 25


  57. "Identifying differential histone modification sites from ChIP-seq data." Xu H, Sung WK (2012) Methods Mol Biol 2012 ; 802 : 293-303


  58. "Institutional Profile: Golden Helix Institute of Biomedical Research: interdisciplinary research and educational activities in pharmacogenomics and personalized medicine." Mitropoulos K, Innocenti F, van Schaik RH, Lezhava A, Tzimas G, Kollia P, Macek M, Fortina P, Patrinos GP (2012) Pharmacogenomics 2012 Mar ; 13(4) : 387-92


  59. "Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival." Tan PY, Chang CW, Chng KR, Wansa KD, Sung WK, Cheung E (2012) Mol Cell Biol 2012 Jan ; 32(2) : 399-414 Epub 2011 Nov 14


  60. "Isorhamnetin Inhibits Proliferation and Invasion and Induces Apoptosis through the Modulation of Peroxisome Proliferator-activated Receptor γ Activation Pathway in Gastric Cancer." Ramachandran L, Manu KA, Shanm ugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G (2012) J Biol Chem 2012 Nov 2 ; 287(45) : 38028-40 Epub 2012 Sep 19


  61. "Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma." Koo GC, Tan SY, Tang T, Poon SL, Allen GE, Tan L, Chong SC, Ong WS, Tay K, Tao M, Quek R, Loong S, Yeoh KW, Yap SP, Lee KA, Lim LC, Tan D, Goh C, Cutcutache I, Yu W, Ng CC, Rajasegaran V, Heng HL, Gan A, Ong CK, Rozen S, Tan P, Teh BT, Lim ST (2012) Cancer Discov 2012 Jul ; 2(7) : 591-7 Epub 2012 Jun 15


  62. "Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium." Verhoeven VJ, Hysi PG, Saw SM, Vitart V, Mirshahi A, Guggenheim JA, Cotch MF, Yamashiro K, Baird PN, Mackey DA, Wojciechowski R, Ikram MK, Hewitt AW, Duggal P, Janmahasatian S, Khor CC, Fan Q, Zhou X, Young TL, Tai ES, Goh LK, Li YJ, Aung T, Vithana E, Teo YY, Tay W, Sim X, Rudan I, Hayward C, Wright AF, Polasek O, Campbell H, Wilson JF, Fleck BW, Nakata I, Yoshimura N, Yamada R, Matsuda F, Ohno-Matsui K, Nag A, McMahon G, Pourcain BS, Lu Y, Rahi JS, Cumberland PM, Bhattacharya S, Simpson CL, Atwood LD, Li X, Raffel LJ, Murgia F, Portas L, Despriet DD, van Koolwijk LM, Wolfram C, Lackner KJ, Tönjes A, Mägi R, Lehtimäki T, Kähönen M, Esko T, Metspalu A, Rantanen T, Pärssinen O, Klein BE, Meitinger T, Spector TD, Oostra BA, Smith AV, de Jon g PT, Hofman A, Amin N, Karssen LC, Rivadeneira F, Vingerling JR, Eiríksdóttir G, Gudnason V, Döring A, Bettecken T, Uitterlinden AG, Williams C, Zeller T, Castagné R, Oexle K, van Duijn CM, Iyengar SK, Mitchell P, Wang JJ, Höhn R, Pfeiffer N, Bailey-Wilson JE, Stambolian D, Wong TY, Hammond CJ, Klaver CC (2012) Hum Genet 2012 Jun 5 Epub 2012 Jun 5


  63. "LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets." Wilm A, Aw PP, Bertrand D, Yeo GH, Ong SH, Wong CH, Khor CC, Petric R, Hibberd ML, Nagarajan N (2012) Nucleic Acids Res 2012 Oct 12


  64. "Long non-coding RNAs in stem cell pluripotency." Ng SY, Stanton LW (2012) Wiley Interdiscip Rev RNA 2012 Nov 8


  65. "Long Span DNA Paired-End-Tag (DNA-PET) Sequencing Strategy for the Interrogation of Genomic Structural Mutations and Fusion-Point-Guided Reconstruction of Amplicons." Yao F, Ariyaratne PN, Hillmer AM, Lee WH, Li G, Teo AS, Woo XY, Zhang Z, Chen JP, Poh WT, Zawack KF, Chan CS, Leong ST, Neo SC, Choi PS, Gao S, Nagarajan N, Thoreau H, Shahab A, Ruan X, Cacheux-Rataboul V, Wei CL, Bourque G, Sung WK, Liu ET, Ruan Y (2012) PLoS One 2012 ; 7(9) : e46152 Epub 2012 Sep 28


  66. "Management of colon cancer: resource-stratified guidelines from the Asian Oncology Summit 2012." Ku G, Tan IB, Yau T, Boku N, Laohavinij S, Cheng AL, Kang YK, de Lima Lopes G (2012) Lancet Oncol 2012 Nov ; 13(11) : e470-81


  67. "Mannose-binding lectin 2 polymorphisms do not influence frequency or type of infection in adults with chemotherapy induced neutropaenia." Wong M, Ohrmalm L, Broliden K, Aust C, Hibberd M, Tolfvenstam T (2012) PLoS One 2012 ; 7(2) : e30819 Epub 2012 Feb 17


  68. "Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations." Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, Takahashi A, Maeda S, Tsunoda T, Chen P, Lim SC, Wong TY, Liu J, Young TL, Aung T, Seielstad M, Teo YY, Kim YJ, Lee JY, Han BG, Kang D, Chen CH, Tsai FJ, Chang LC, Fann SJ, Mei H, Rao DC, Hixson JE, Chen S, Katsuya T, Isono M, Ogihara T, Chambers JC, Zhang W, Kooner JS, Albrecht E, Yamamoto K, Kubo M, Nakamura Y, Kamatani N, Kato N, He J, Chen YT, Cho YS, Tai ES, Tanaka T (2012) Nat Genet 2012 ; 44(8) : 904-909 Epub 2012 Jul 15


  69. "Methylation subtypes and large-scale epigenetic alterations in gastric cancer." Zouridis H, Deng N, Ivanova T, Zhu Y, Wong B, Huang D, Wu YH, Wu Y, Tan IB, Liem N, Gopalakrishnan V, Luo Q, Wu J, Lee M, Yong WP, Goh LK, Teh BT, Rozen S, Tan P (2012) Sci Transl Med 2012 Oct 17 ; 4(156) : 156ra140


  70. "Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells." Siu CW, Lee YK, Ho JC, Lai WH, Chan YC, Ng KM, Wong LY, Au KW, Lau YM, Zhang J, Lay KW, Colman A, Tse HF (2012) Aging (Albany NY) 2012 Nov ; 4(11) : 803-822


  71. "Modulation of Caenorhabditis elegans infection sensitivity by the LIN-7 cell junction protein." Sem X, Kreisberg JF, Kawli T, Tan MW, Rhen M, Tan P (2012) Cell Microbiol 2012 Oct ; 14(10) : 1584-99 Epub 2012 Jun 21


  72. "Mouse strain specific gene expression differences for Illumina microarray expression profiling in embryos." Kraus P, Xing X, Lim SL, Fun ME, Sivakamasundari V, Yap SP, Lee H, Karuturi RK, Lufkin T (2012) BMC Res Notes 2012 May 14 ; 5(1) : 232 Epub 2012 May 14


  73. "Nanofiber topography and sustained biochemical signaling enhance human mesenchymal stem cell neural commitment." Jiang X, Cao HQ, Shi LY, Ng SY, Stanton LW, Chew SY (2012) Acta Biomater 2012 Mar ; 8(3) : 1290-302 Epub 2011 Nov 20


  74. "Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming." Percharde M, Lavial F, Ng JH, Kumar V, Tomaz RA, Martin N, Yeo JC, Gil J, Prabhakar S, Ng HH, Parker MG, Azuara V (2012) Genes Dev 2012 Oct 15 ; 26(20) : 2286-98 Epub 2012 Sep 26


  75. "Neural stem cell specific fluorescent chemical probe binding to FABP7." Yun SW, Leong C, Zhai D, Tan YL, Lim L, Bi X, Lee JJ, Kim HJ, Kang NY, Ng SH, Stanton LW, Chang YT (2012) Proc Natl Acad Sci U S A 2012 Jun 11


  76. "Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1." Siggens L, Figg N, Bennett M, Foo R (2012) FASEB J 2012 May ; 26(5) : 2117-24 Epub 2012 Feb 1


  77. "One pot synthesis and anticancer activity of dimeric phloroglucinols." Chauthe SK, Bharate SB, Periyasamy G, Khanna A, Bhutani KK, Mishra PD, Singh IP (2012) Bioorg Med Chem Lett 2012 Mar 15 ; 22(6) : 2251-6 Epub 2012 Jan 31


  78. "One-step detection of the 2009 pandemic influenza A(H1N1) virus by the RT-SmartAmp assay and its clinical validation." Kawai Y, Kimura Y, Lezhava A, Kanamori H, Usui K, Hanami T, Soma T, Morlighem JÉ, Saga S, Ishizu Y, Aoki S, Endo R, Oguchi-Katayama A, Kogo Y, Mitani Y, Ishidao T, Kawakami C, Kurata H, Furuya Y, Saito T, Okazaki N, Chikahira M, Hayashi E, Tsuruoka S, Toguchi T, Saito Y, Ban T, Izumi S, Uryu H, Kudo K, Sakai-Tagawa Y, Kawaoka Y, Hirai A, Hayashizaki Y, Ishikawa T (2012) PLoS One 2012 ; 7(1) : e30236 Epub 2012 Jan 25


  79. "Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians." Png E, Alisjahbana B, Sahiratmadja E, Marzuki S, Nelwan R, Adnan I, van de Vosse E, Hibberd M, van Crevel R, Ottenhoff TH, Seielstad M (2012) Infect Genet Evol 2012 Apr 12


  80. "PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation." Covey TM, Kaur S, Tan Ong T, Proffitt KD, Wu Y, Tan P, Virshup DM (2012) PLoS One 2012 ; 7(4) : e34532 Epub 2012 Apr 11


  81. "Predicting cancer drivers: are we there yet?" Krishnan VG, Ng PC (2012) Genome Med 2012 Nov 26 ; 4(11) : 88 Epub 2012 Nov 26


  82. "Predicting the effects of frameshifting indels." Hu J, Ng PC (2012) Genome Biol 2012 Feb 9 ; 13(2) : R9 Epub 2012 Feb 9


  83. "Prevalence of Streptococcus pneumoniae serotypes causing invasive and non-invasive disease in South East Asia: A review." Jauneikaite E, Jefferies JM, Hibberd ML, Clarke SC (2012) Vaccine 2012 Apr 1


  84. "Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation." Soldati C, Bithell A, Johnston C, Wong KY, Teng SW, Beglopoulos V, Stanton LW, Buckley NJ (2012) Stem Cells 2012 Mar ; 30(3) : 425-34


  85. "SIFT web server: predicting effects of amino acid substitutions on proteins." Sim NL, Kumar P, Hu J, Henikoff S, Schneider G, Ng PC (2012) Nucleic Acids Res 2012 Jul ; 40(Web Server issue) : W452-7 Epub 2012 Jun 11


  86. "Single-Cell mRNA Profiling Identifies Progenitor Subclasses in Neurospheres." Narayanan G, Poonepalli A, Chen J, Sankaran S, Hariharan S, Yu YH, Robson P, Yang H, Ahmed S (2012) Stem Cells Dev 2012 Sep 10


  87. "Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases." Li R, Brockschmidt FF, Kiefer AK, Stefansson H, Nyholt DR, Song K, Vermeulen SH, Kanoni S, Glass D, Medland SE, Dimitriou M, Waterworth D, Tung JY, Ge ller F, Heilmann S, Hillmer AM, Bataille V, Eigelsh oven S, Hanneken S, Moebus S, Herold C, den Heijer M, Montgomery GW, Deloukas P, Eriksson N, Heath AC, Becker T, Sulem P, Mangino M, Vollenweider P, Spector TD, Dedoussis G, Martin NG, Kiemeney LA, Mooser V, Stefansson K, Hinds DA, Nöthen MM, Richards JB (2012) PLoS Genet 2012 May ; 8(5) : e1002746 Epub 2012 May 31


  88. "STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation." Tye H, Kennedy CL, Najdovska M, McLeod L, McCormack W, Hughes N, Dev A, Sievert W, Ooi CH, Ishikawa TO, Oshima H, Bhathal PS, Parker AE, Oshima M, Tan P, Jenkins BJ (2012) Cancer Cell 2012 Oct 16 ; 22(4) : 466-78


  89. "Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206." Liang Y, Huimei Hong F, Ganesan P, Jiang S, Jauch R, Stanton LW, Kolatkar PR (2012) Nucleic Acids Res 2012 Jun 26


  90. "Study Sequence Rules of ERα - DNA Interactions Using Dual Polarisation Interferometry and Computational Modeling." Song HY, Sun W, Prabhakar S, Aung KM, Su X (2012) Anal Biochem 2012 Oct 22


  91. "Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors." Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M (2012) PLoS Genet 2012 May ; 8(5) : e1002728 Epub 2012 May 17


  92. "The draft genome of sweet orange (Citrus sinensis)." Xu Q, Chen LL, Ruan X, Chen D, Zhu A, Chen C, Bertrand D, Jiao WB, Hao BH, Lyon MP, Chen J, Gao S, Xing F, Lan H, Chang JW, Ge X, Lei Y, Hu Q, Miao Y, Wang L, Xiao S, Biswas MK, Zeng W, Guo F, Cao H, Yang X, Xu XW, Cheng YJ, Xu J, Liu JH, Luo OJ, Tang Z, Guo WW, Kuang H, Zhang HY, Roose ML, Nagarajan N, Deng XX, Ruan Y (2012) Nat Genet 2012 Dec 16 ; 45(1) : 59-66 Epub 2012 Nov 25


  93. "The landscape of DNA repeat elements in human heart failure." Haider S, Cordeddu L, Robinson E, Movassagh M, Siggens L, Vujic A, Choy MK, Goddard M, Lio P, Foo R (2012) Genome Biol 2012 Oct 3 ; 13(10) : R90 Epub 2012 Oct 3


  94. "The SmartAmp method: rapid detection of SNPs in thiopurine S-methyltransferase and ABC transporters ABCC4 and ABCG2." Aw W, Lezhava A, Andoh A, Tanaka H, Hayashizaki Y, Ishikawa T (2012) Curr Drug Metab 2012 Sep 1 ; 13(7) : 968-77


  95. "Toll-like receptor 2: therapeutic target for gastric carcinogenesis." McCormack W, Oshima M, Tan P, Jenkins B (2012) Oncotarget 2012 Nov ; 3(11) : 1260-1


  96. "TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep)." Cheng LL, Itahana Y, Lei ZD, Chia NY, Wu Y, Yu Y, Zhang SL, Thike AA, Pandey A, Rozen S, Voorhoeve PM, Yu Q, Tan PH, Bay BH, Itahana K, Tan P (2012) Clin Cancer Res 2012 Aug 1 ; 18(15) : 4201-12 Epub 2012 Jun 6


  97. "Understanding the genetic basis of gastric cancer: recent advances." Tan IB, Ng I, Tai WM, Tan P (2012) tol 2012 Jun ; 6(3) : 335-41


  98. "Whole-genome and whole-exome sequencing in neurological diseases." Foo JN, Liu JJ, Tan EK (2012) Nat Rev Neurol 2012 Jul 31 Epub 2012 Jul 31


  99. "Whole-genome reconstruction and mutational signatures in gastric cancer." Nagarajan N, Bertrand D, Hillmer AM, Zang ZJ, Yao F, Jacques PE, Teo AS, Cutcutache I, Zhang Z, Lee WH, Sia YY, Gao S, Ariyaratne PN, Ho A, Woo XY, Veeravali L, Ong CK, Deng N, Desai KV, Khor CC, Hibberd ML, Shahab A, Rao J, Wu M, Teh M, Zhu F, Chin SY, Pang B, So JB, Bourque G, Soong R, Sung WK, Teh BT, Rozen S, Ruan X, Yeoh KG, Tan PB, Ruan Y (2012) Genome Biol 2012 Dec 13 ; 13(12) : R115 Epub 2012 Dec 13


  100. "Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain." Rogelj B, Easton LE, Bogu GK, Stanton LW, Rot G, Curk T, Zupan B, Sugimoto Y, Modic M, Haberman N, Tollervey J, Fujii R, Takumi T, Shaw CE, Ule J (2012) Sci Rep 2012 ; 2 : 603 Epub 2012 Aug 28


  101. "X-Linked Megalocornea Caused by Mutations in CHRDL1 Identifies an Essential Role for Ventroptin in Anterior Segment Development." Webb TR, Matarin M, Gardner JC, Kelberman D, Hassan H, Ang W, Michaelides M, Ruddle JB, Pennell CE, Yazar S, Khor CC, Aung T, Yogarajah M, Robson AG, Holder GE, Cheetham ME, Traboulsi EI, Moore AT, Sowden JC, Sisodiya SM, Mackey DA, Tuft SJ, Hardcastle AJ (2012) Am J Hum Genet 2012 Jan 24


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