Research Highlights
Cancer biology: The two faces of a cancer signal
01 February 2012
"A protein in breast cancer cells acts as a bidirectional switch to modulate inflammatory gene expression"...more
Medical genetics: Markers for bone-fusion disease
18 January 2012
"A genome-wide association study has identified genetic variations associated with the debilitating disease ankylosing spondylitis"...more
Genomics: Malignant rearrangements
07 December 2011
"DNA sequencing reveals how breast cancer cells rearrange their genome to create fusion genes for driving tumor development"...more
Genomics: Sorting through the damage
23 November 2011
"A high-throughput sequencing strategy allows scientists to follow cancer’s trail of genomic destruction"...more
Molecular genetics: A collective effort
06 November 2011
"Gene regulation may depend more on the synergy of multiple proteins rather than discrete contributions of individual factors"...more
Developmental biology: Delayed polyadenylation of maternal mRNA
26 October 2011
"An atlas of embryonic stage-specific gene expression in fish provides insights into a long-standing enigma of the developmental process"...more
Cancer biology: Aggravating tumor aggressiveness
12 October 2011
"A protein secreted from breast cancer cells enhances the spread and survival of tumor cells"...more
Cancer biology: The origin of esophageal cancer
28 September 2011
"A new model for the origin of Barrett’s esophagus could lead to improved early treatment of esophageal cancer"...more
Stem cells: Differentiation in the balance
14 September 2011
"The differentiation of stem cells into particular fetal cell lineages is a precarious affair acted out on a molecular battlefield"...more
Medical genetics: Markers for lymphoma
03 August 2011
"Two genetic variants on chromosome 6 are associated with lymphoma"...more
Stem cells: Reprogramming with synthetic proteins
06 July 2011
"Genetically engineered proteins can be used to revert cells back to their undifferentiated state"...more
Molecular genetics: Size matters
25 May 2011
"Variations in three genes can affect the size of the optic disc, a structure in the eye that is larger in individuals with visual dysfunction"...more
Neuroscience: Gut instincts
11 May 2011
"Understanding the intimate connections between microbes and development could lead to better treatment of disease"...more
Virology: Flu tracking
13 April 2011
"A computational algorithm for tracking influenza viral ancestry outperforms even human experts"...more
Stem cells: Essential factors
02 March 2011
"A genome-wide RNA interference screen identifies genes that govern the unique properties of human embryonic stem cells"...more
Cancer biology: A back door to drug resistance
22 December 2010
"An investigation into how some cancers evade treatment reveals a novel pathway regulating tumor growth"...more
Medical genetics: Many a little makes a mickle
10 November 2010
"Genetic variations related to estrogen production have a cumulative effect on breast and endometrial cancer risk"...more
Stem cells: Brighten up
10 November 2010
"A fluorescent probe that selectively highlights embryonic and induced pluripotent stem cells is now available"...more
Medical genetics: Susceptibility loci for meningococcal disease
13 October 2010
"A genome-wide association study identifies genetic factors that increase the risk of meningococcal disease"...more
Stem cells: Driving differentiation
15 September 2010
"Mysterious molecules called lncRNA direct the fate of stem cells in the early mouse embryo"...more
Finding the best approach in cancer research
01 September 2010
"Cancer geneticists in Singapore seek clinical relevance in large-scale cancer genomics studies."...more
Biosensors: Color-coding hormone tricksters
01 September 2010
"Gold nanoparticles power a quick and colorful method to detect protein-DNA interactions with nucleotide-specific sensitivity"...more
Cancer biology: On the trail of an elusive tumor
01 September 2010
"A large-scale genomic analysis yields insights into a cancer that disproportionately affects individuals from southern China"...more
Genomics: Revealing a regulatory divide
18 August 2010
"Mammalian genomes display large differences where the regulatory proteins of their embryonic stem cells bind"...more
Genetics: Deletion reveals neuron loss
04 August 2010
"Zebrafish provide clues to the function of a key Parkinson's disease gene"...more
Immunology: Signaling disease
21 July 2010
"Individuals carrying variants of a gene involved in controlling the immune response are prone to infection"...more
Cancer biology: A matter of life or death
07 July 2010
"Inactivation of a protective cellular `self-destruct' mechanism enables cancer cells to grow without restraint"...more
Infectious disease: Stopping flu in its tracks
23 June 2010
"A containment-oriented treatment strategy may help limit spread of influenza in schools and hospitals"...more
Development: Getting with the program
09 June 2010
"Single-cell gene expression profiling reveals specific genetic programs underlying cell differentiation in pre-implantation mouse embryos"...more
Infectious disease: Swine flu under surveillance
09 June 2010
"An efficient tool for monitoring the emergence and spread of new H1N1 virus variants has been developed in Singapore"...more
Tackling the ever-growing threat of dengue fever
12 May 2010
"Scientists at A*STAR are taking a diversified approach to combating dengue fever, an infectious tropical disease that is fast becoming a major global threat to health and the economy"...more
Genetics: Revealing hidden vulnerabilities
14 April 2010
"The International Kawasaki Disease Genetics Consortium uncovers multiple genes potentially involved in an enigmatic childhood disease"...more
Genetics: Colitis research takes guts
14 April 2010
"A large-scale genomic study identifies genes associated with bowel disease and provides clues to their functions"...more
Stem cells: Quality improvement
31 March 2010
"Reprogrammed adult cells can display different qualities depending on how they were generated"...more
Genetics: Building a multi-national family tree
31 March 2010
"Geneticists from across Asia have come together to build a continent-spanning map of genetic diversity"...more
Genetics: More diversity than meets the eye
17 February 2010
"Large-scale analysis of Han Chinese populations reveals striking patterns of intriguing genetic diversity"...more
MicroRNA: Keeping death in check
20 January 2010
"A small RNA molecule has a big influence on the activity of an important tumor suppressor"...more
Cancer biology: Finding patterns in repetition
20 January 2010
"A sophisticated algorithm combines expression data with information about patient outcomes to reveal cancer genes"...more
Dengue fever: epidemic ignited by environmental conditions
09 December 2009
"Findings from an intensive genomic study contradict the conventional explanation-viral mutation-as the cause of dengue fever outbreaks"...more
Stem cells: A new part of the program
11 November 2009
"A novel transcription factor can facilitate the reprogramming of somatic cells into stem cells"...more
Systems Biomedicine: Concepts and Perspectives
28 October 2009
"A new book by A*STAR's Edison Liu and Douglas Lauffenburger of the Massachusetts Institute of Technology explores systems complexity in biomedical research"...more
